Tryptophan Hydroxylase 1 (TPH1) Recombinant Rabbit Monoclonal Antibody [SC53-07]

About this product

Phenylalanine hydroxylase (PAH), tyrosine hydroxylase (TH) and tryptophan hydroxylase (TPH) comprise a small family of monooxygenases that use tetrahydropterine as a cofactor during the catabolism of aromatic L-amino acids. PAH, TH and TPH all contain catalytic domains with an amino-terminal regulatory domain and a short carboxy-terminal tetramerization domain. Each of these enzymes also contains a single ferrous iron atom, which is bound to two histidines and a glutamate and is likely to be involved in the formation of the hydroxylating intermediate. TPH is the first and rate-limiting step in the biosynthesis of serotonin in the central nervous system and melatonin in the pineal gland. Alteration of TPH function may be a key factor in the pathology of several neuropsychiatric disorders associated with serotonin, including depression, aggression, alcoholism and schizophrenia. For instance, L-DOPA, which is used as a common therapy for Parkinson’s disease (PD) patients, inhibits TPH function, which subsequently, is thought to contribute to the onset of depression in PD patients.

Specifications

Catalog number

ET1610-37

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

Indoleacetic acid 5 hydroxylase antibody L tryptophan hydroxylase antibody MGC119994 antibody TPH 1 antibody TPH antibody TPH1 antibody TPH1_HUMAN antibody TPRH antibody TRPH antibody Tryptophan 5 hydroxylase 1 antibody Tryptophan 5 monooxygenase 1 antibody Tryptophan 5 monooxygenase antibody Tryptophan 5-hydroxylase 1 antibody Tryptophan 5-monooxygenase 1 antibody Tryptophan hydroxylase 1 antibody

Abbreviation

TPH1

Swiss Prot

P17752 Human, P17532 Mouse, P09810 Rat

Cellular Locus

Cytosol, neuron projection.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human TPH1 aa 372-419 / 444.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HL-60 cell lysate, Hela cell lysate, rat brain tissue, mouse cerebellum tissue, Hela.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes