hnRNP K Recombinant Rabbit Monoclonal Antibody [SC60-03]

About this product

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of poly-peptides that contribute to mRNA transcription and pre-mRNA processing as well as mature mRNA transport to the cytoplasm and translation. They also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA Polymerase II. There are approximately 20 known hnRNP proteins and their complexes are the major constituents of the spliceosome. The majority of hnRNP protein are localized to the nucleus, however some shuttle between the nucleus and the cytoplasm, such as hnRNP K. hnRNP K recruits a variety of molecular partners through two K homologous (KH) domains, which are required for protein-protein interactions. hnRNP K also contains several potential phosphorylation sites, including Ser 302, the major site of PKCd phosphorylation, which are thought to regulate various cellular functions, including sequence-specific DNA binding, transcription, RNA binding and nucleocytoplasmic shuttling.

Specifications

Catalog number

ET1610-38

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CSBP antibody dC stretch binding protein antibody FLJ41122 antibody Heterogeneous nuclear ribonucleoprotein K antibody hnRNP K antibody HNRNPK antibody HNRPK antibody HNRPK_HUMAN antibody Transformation up regulated nuclear protein antibody Transformation up-regulated nuclear protein antibody Transformation upregulated nuclear protein antibody TUNP antibody

Abbreviation

hnRNP K, TUNP, HNRNPK

Swiss Prot

P61978 Human, P61979 Mouse, P61980 Rat

Cellular Locus

Nucleoplasm, Cytoplasm, podosome

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human hnRNP K aa 1-49 / 463.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

HeLa cell lysate, PC-12 cell lysate, mouse thymus tissue lysate, rat thymus tissue lysate, Hela, HepG2, SKOV-3, human colon carcinoma tissue, mouse brain tissue, human breast carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes