Cardiac Troponin T Recombinant Rabbit Monoclonal Antibody [SC64-03]

About this product

Actin is a highly conserved protein that is expressed in all eukaryotic cells. Actin filaments can form both stable and labile structures and are crucial components of microvilli and the contractile apparatus of muscle cells. Myosin is a hexamer of two heavy chains (MHC) and four light chains (MLC) that interacts with Actin to generate the force for diverse cellular movements, including cytokinesis, phagocytosis and muscle contraction. Troponin facilitates the interaction between Actin and Myosin by binding to calcium. Troponin is made up of at least two subunits, which are divergent in cardiac muscle, fast skeletal muscle and slow skeletal muscle. Structures of skeletal muscle troponin are composed of Troponin C (the sensor), Troponin I (the regulator) and Troponin T (the link to the muscle thin filament). Troponin C is dumbbell-shaped and has a hydrophobic pocket that increases the contractile force of muscle fibers. Troponin C has two isoforms: fast and slow. Fast Troponin C has two calcium binding sites, while slow/cardiac Troponin C has a single calcium binding site.

Specifications

Catalog number

ET1610-51

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Cardiac muscle troponin T antibody Cardiomyopathy dilated 1D (autosomal dominant) antibody Cardiomyopathy hypertrophic 2 antibody CMD1D antibody CMH2 antibody CMPD2 antibody cTnT antibody LVNC6 antibody MGC3889 antibody OTTHUMP00000033864 antibody OTTHUMP00000033865 antibody OTTHUMP00000033866 antibody OTTHUMP00000033867 antibody OTTHUMP00000033870 antibody OTTHUMP00000218095 antibody RCM3 antibody TNNT 2 antibody TNNT2 antibody TNNT2_HUMAN antibody TnTc antibody Troponin T cardiac muscle antibody Troponin T type 2 (cardiac) antibody Troponin T type 2 cardiac antibody Troponin T, cardiac muscle antibody Troponin T2 cardiac antibody

Abbreviation

TnTc, cTnT, TNNT2

Swiss Prot

P45379 Human, P50752 Mouse, P50753 Rat

Cellular Locus

Cytoplasm, filament.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human Cardiac Troponin T aa 251-298/298.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Tissue

Positive Control

Mouse heart tissue lysates, mouse heart tissue, rat heart tissue lysates, human striated muscle tissue, rat heart tissue, human heart tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500 ;IHC-P: 1:100-1:500 ;IF-Tissue: 1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

36 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes