Phospho-SMC1 (S957) Recombinant Rabbit Monoclonal Antibody [SC65-03]

About this product

The SMC (structural maintenance of chromosomes) family of proteins form heterodimeric complexes that modulate sister chromatid cohesion and chromosome condensation for mitosis. The two distinct classes of SMC protein complexes are comprised of SMC1 (also designated SB1.8) with SMC3 (also designated HCAP for human chromosome-associated protein and Bamacan for the secreted proteoglycan), and SMC2 (also designated hCAP-E) with SMC4 (also designated hCAP-C). The SMC1/SMC3 complex is required for metaphase progression in mitotic cells and functions independently of the SMC2/SMC4 complex during the cell cycle. SMC1 is ubiqitiously expressed in various human tissues, including thymus, testis and colon. SMC3 is expressed as a nuclear protein in the colon, but can also occur as a secreted proteoglycan expressed in testis and brain. The secreted proteoglycan contains several glycosylation sites and is thought to play a role in basement membrane physiology.

Specifications

Catalog number

ET1610-55

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CDLS2 antibody DKFZp686L19178 antibody DXhXs423e antibody DXS423E antibody KIAA0178 antibody MGC138332 antibody OTTHUMP00000061876 antibody RP6 29D12.1 antibody SB1.8 antibody Segregation of mitotic chromosomes 1 antibody Segregation of mitotic chromosomes like 1 antibody SMC 1 antibody SMC protein 1B antibody SMC-1-beta antibody SMC-1B antibody SMC1 antibody SMC1A antibody SMC1alpha antibody SMC1alpha protein antibody SMC1B antibody SMC1B_HUMAN antibody SMC1BETA antibody SMC1beta protein antibody SMC1L1 antibody SMC1L2 antibody SMCB antibody Structural maintenance of chromosome 1 like 1 protein antibody Structural maintenance of chromosome 1 like 2 protein antibody Structural maintenance of chromosomes 1A antibody Structural maintenance of chromosomes 1B antibody Structural maintenance of chromosomes protein 1B antibody

Abbreviation

SMC protein 1A, SMC-1-alpha, SMC-1A, SMC1A, SMC protein 1B, SMC-1-beta, SMC-1B, SMC1B

Swiss Prot

Q8NDV3 Human, Q14683 Human

Cellular Locus

Nucleus, Chromosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Ser957 of Human SMC1 aa 945-980 / 1233.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Cell

Positive Control

HeLa cell lysate, HeLa treated with UV then recovery 30 minutes cell lysate, HeLa cells treated with UV then recovery 30 minutes, human tonsil tissue, human lung adenocarcinoma tissue, human breast carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P:1:50-1:200 ;IF-Cell: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 144 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes