GART Recombinant Rabbit Monoclonal Antibody [SC66-02]

About this product

Purines are critical for energy metabolism, cell signaling and cell reproduction and also function as precursors for coenzymes, energy transfer molecules, regulatory factors and proteins involved in RNA and DNA synthesis. GART (GAR transformylase), also referred to as AIRS, GARS, PAIS, PGFT, PRGS or GARTF, is 1,010 amino acids in length and is a key folate-dependent trifunctional enzyme with phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase and AICAR (phosphoribosylaminoimidazole synthetase) activity required for de novo purine biosynthesis. Cancer cells require considerable amounts of purines to sustain their accelerated growth and GART is, therefore, a target for cancer chemotherapy. GART is highly conserved in vertebrates. Two isoforms of GART are expressed due to alternative splicing events.

Specifications

Catalog number

ET1610-68

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

5'-phosphoribosylglycinamide transformylase antibody AIR synthase antibody AIRS antibody GAR transformylase antibody GARS antibody GART antibody GARTF antibody Glycinamide ribonucleotide synthetase antibody MGC47764 antibody PAIS antibody PGFT antibody Phosphoribosyl-aminoimidazole synthetase antibody Phosphoribosylglycinamide formyltransferase antibody Phosphoribosylglycinamide formyltransferase phosphoribosylglycinamide synthetase phosphoribosylaminoimidazole synthetase antibody Phosphoribosylglycinamide formyltransferase, EC 2.1.2.29 antibody Phosphoribosylglycinamide formyltransferase, phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase antibody Phosphoribosylglycinamide synthetase antibody PRGS antibody PUR2_HUMAN antibody Trifunctional purine biosynthetic protein adenosine 3 antibody

Abbreviation

GARS, AIRS, GART

Swiss Prot

P22102 Human, Q64737 Mouse

Cellular Locus

Cytoplasm, Nucleus, Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human GART aa 570-750 / 1010.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

Hela cell lysate, A431 cell lysate, Hela, HepG2, SW480, human tonsil tissue, mouse uterus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 108 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes