WASF2 Recombinant Rabbit Monoclonal Antibody [SC66-05]

About this product

WASP (for Wiskott-Aldrich syndrome protein) and N-WASP are downstream effectors of Cdc42 that are implicated in Actin polymerization and cytoskeletal organization. The WASP family also includes VASP (vasodilator-stimulated phosphoprotein) and Mena (for mammalian enabled protein), which accumulate at focal adhesions and are also involved in the regulation of the Actin cytoskeleton. The WAVE proteins are related to the WASP family proteins and are likewise involved in mediating Actin reorganization downstream of the Rho family of small GTPases. The protein homologs WAVE1 and WAVE2 regulate membrane ruffling by inducing the formation of Actin filament clusters in response to GTP binding and by activating Rac. They mediate Actin polymerization by cooperating with the Arp2/3 complex, thereby promoting the formation of Actin filaments. WAVE1, which is also designated SCAR (suppressor of cAR), is expressed primarily in the brain, while WAVE2 is widely expressed, with the expression highest in peripheral blood leukocytes. WAVE3 forms a multiprotein complex that links receptor kinases with Actin and plays a role in the transduction of signals involving changes in cell shape, function or motility.

Specifications

Catalog number

ET1610-69

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

DICTYOSTELIUM antibody dJ393P12.2 antibody IMD2 antibody Protein WAVE-2 antibody Putative Wiskott Aldrich syndrome protein family member 4 antibody SCAR 2 antibody SCAR antibody SCAR2 antibody Suppressor of cyclic-AMP receptor (WASP family) antibody Verprolin homology domain-containing protein 2 antibody WASF2 antibody WASF2_HUMAN antibody WASF4 antibody WASP family protein member 2 antibody WASP family protein member 4 antibody WASP family Verprolin homologous protein 2 antibody WASP-family protein member 2 antibody WAVE 2 antibody WAVE2 antibody Wiskott-Aldrich syndrome protein family member 2 antibody Wiskott-Aldrich syndrome protein family verprolin-homologous protein antibody

Abbreviation

WASP family protein member 2, WASF2

Swiss Prot

Q9Y6W5 Human, Q8BH43 Mouse,

Cellular Locus

Basolateral cell membrane, cytoskeleton, lamellipodium.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human WASF2 aa 440-485 / 498.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Human placenta tissue lysates, human kidney tissue, mouse kidney tissue, mouse placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

54 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes