Daxx Recombinant Rabbit Monoclonal Antibody [SC54-06]

About this product

Activation of the cell surface receptor FAS by FAS ligand leads to the initiation of apoptosis, a process necessary for the regulation of the immune system and tissue homeostasis. FAS-mediated apoptosis appears to involve a number of divergent and overlapping pathways. Daxx appears to be a central component of a FAS-mediated apoptotic pathway involving the activation of Jun N-terminal kinase (JNK). Although Daxx itself does not contain a death domain, it specifically binds to the death domain of FAS. Overexpression of Daxx activates the JNK pathway and enhances FAS-mediated apoptosis. The Daxx apoptotic pathway acts cooperatively with but is distinct from the FAS-mediated pathway that involves interactions between the death domain-containing protein FADD and the cysteine protease FLICE. Unlike the FAS-FADD-FLICE pathway, the Daxx pathway is sensitive to the apoptotic inhibitor protein Bcl-2.

Specifications

Catalog number

ET1610-7

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

BING 2 antibody BING2 antibody CENP-C binding protein antibody DAP 6 antibody DAP6 antibody DAXX antibody DAXX_HUMAN antibody Death associated protein 6 antibody Death domain associated protein 6 antibody Death domain associated protein antibody Death domain-associated protein 6 antibody EAP 1 antibody EAP1 antibody ETS1 associated protein 1 antibody ETS1-associated protein 1 antibody Fas binding protein antibody Fas death domain associated protein antibody Fas death domain-associated protein antibody hDaxx antibody MGC126245 antibody MGC126246 antibody

Abbreviation

hDaxx, EAP1

Swiss Prot

Q9UER7 Human

Cellular Locus

Cytoplasm, Nucleus, Chromosome.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Daxx aa 195-313 / 740.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, FC

Positive Control

PANC-1, A549, Hela, SW480.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000;IF-Cell: 1:50-1:200;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

81 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes