TCF7L2 Recombinant Rabbit Monoclonal Antibody [SC06-90]

About this product

T cell factors (TCFs) comprise a family of DNA-binding transcriptional activators that are essential for lymphoid cell development. These transcription factors are activated by the Wnt-1 and Wingless pathways and are characterized by the presence of a conserved protein motif, the high mobility group (HMG) 1 box, which mediates DNA binding. TCF-4 mainly localizes in the cytoplasm and is transported into the nucleus directly bound to β-catenin in a cooperative manner. This TCF-4/β-catenin complex induces expression of Wnt target genes, including multiple cancer-associated genes. c-Jun also interacts with TCF-4 and β-catenin, and the phosphorylation-dependent interaction between c-Jun and TCF4 regulates intestinal tumorigenesis by integrating JNK and APC/β-catenin. TCF-4 is also implicated in bipolar affective disorder.

Specifications

Catalog number

ET1610-73

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

HMG box transcription factor 4 antibody hTCF 4 antibody hTCF-4 antibody T cell factor 4 antibody T cell specific HMG box antibody T cell specific transcription factor 4 antibody T-cell factor 4 antibody T-cell-specific transcription factor 4 antibody TCF 4 antibody TCF-4 antibody TCF4 antibody TCF7L2 antibody TCF7L2 protein antibody TF7L2_HUMAN antibody Transcription factor 7 like 2 antibody Transcription factor 7 like 2 T cell specific HMG box antibody Transcription factor 7-like 2 antibody

Abbreviation

T-cell factor 4, TCF-4, hTCF-4, TCF7L2

Swiss Prot

Q9NQB0 Human, Q924A0 Mouse

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human TCF7L2 aa 1-49 / 619.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HepG2 cell lysate, HeLa cell lysate, HeLa, mouse brain tissue, mouse hippocampus tissue, mouse testis tissue, rat testis tissue, human breast carcinoma tissue, human kidney tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:1,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 68 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes