DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06] — image 1 of 3

Product details

DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06]

Catalog number ET1610-74

Price for ET1610-74

Size / count 100 µL

About this product

The activation of caspases is a key regulatory step in apoptosis. Once cytochrome c is released from the mitochondria into the cytosol, it binds Apaf-1 to form an oligomeric cytochrome c/Apaf-1 complex, which induces caspase activation. Inhibitors of Apoptosis Proteins (IAPs), are a family of proteins that regulate the cytochrome c/Apaf-1 caspase activating pathway. Like cytochrome c, Smac (for second mitochondria-derived activator of caspase, also designated DIABLO in mouse for direct IAP binding protein with low PI) promotes caspase activation in the cytochrome c/Apaf-1/caspase-9 pathway by binding IAPs and preventing them from inhibiting caspases. In healthy cells, Smac is a mitochondrial protein, but when cells undergo apoptosis, Smac is released into the cytosol.

Specifications

Catalog number: ET1610-74
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: 0610041G12Rik antibody DBLOH_HUMAN antibody DBOH antibody DFNA64 antibody diablo antibody Diablo homolog (Drosophila) antibody Diablo homolog antibody Diablo homolog mitochondrial antibody Diablo IAP binding mitochondrial protein antibody Diablo like protein antibody DIABLO S antibody Direct IAP binding protein with low pI antibody Direct IAP-binding protein with low pI antibody FLJ10537 antibody FLJ25049 antibody mitochondrial antibody Mitochondrial Smac protein antibody Second mitochondria derived activator of caspase antibody Second mitochondria-derived activator of caspase antibody SMAC 3 antibody Smac antibody Smac protein antibody SMAC3 antibody
Abbreviation: Smac, DIABLO
Swiss Prot: Q9NR28 Human, Q9JIQ3 Mouse
Cellular Locus: Mitochondrion.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human DIABLO aa 190-239 / 239.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Positive Control: HeLa cell lysate, Jurkat cell lysate, C6 cell lysate, mouse testis tissue lysate, rat testis tissue lysate, Hela, B16-F1, LO2, N2A, human spleen tissue, mouse overy tissue, mouse skin tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 27 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06]?

The catalog number for DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06] is ET1610-74.

What sizes are available for DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06]?

DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06] is available in the following size(s): 100 µL.

Is DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06] in stock?

DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06] is currently made to order / not held in immediate stock. Contact us for lead time.

What is DIABLO Recombinant Rabbit Monoclonal Antibody [SC67-06] used for?

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.

Does this product need any special customs documentation to be imported to my country?

If you’re outside the EU, UK, or USA, you’re responsible for customs clearance and any related taxes or fees. We provide the standard import documents, such as the Commercial Invoice, Packing List, and Airway Bill, in advance, so let us know early if your customs office needs anything additional for this specific product.