Integrin linked ILK Recombinant Rabbit Monoclonal Antibody [SC68-04]

About this product

Integrins are heterodimers composed of non-covalently associated transmembrane a and b subunits. The 16 a and 8 b subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind to ligands that are components of the extracellular matrix. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells, such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis. ILK (integrin-linked kinase) was identified as a serine/threonine kinase that phosphorylates b1 and b3 integrins. ILK expression has been shown to be reduced in response to Fibronectin, a known integrin ligand. Overexpression of ILK was shown to upregulate the Fibronectin matrix assembly in epithelial cells, indicating a potential role for ILK in cell growth, cell survival and tumorigenesis.

Specifications

Catalog number

ET1610-76

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

59 kDa serine/threonine protein kinase antibody 59 kDa serine/threonine-protein kinase antibody DKFZp686F1765 antibody Epididymis secretory protein Li 28 antibody HEL S 28 antibody ILK 1 antibody ILK 2 antibody ILK antibody ILK-1 antibody ILK-2 antibody ILK_HUMAN antibody ILK1 antibody ILK2 antibody Integrin linked kinase 2 antibody Integrin linked Kinase antibody Integrin linked protein kinase antibody Integrin-linked protein kinase antibody p59 antibody p59ILK antibody

Abbreviation

ILK

Swiss Prot

Q13418 Human, O55222 Mouse, Q99J82 Rat

Cellular Locus

Cell junction, Cell membrane, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within human Integrin linked ILK aa 410-452.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP, FC

Positive Control

Hela cell lysate, 293T cell lysate, NIH/3T3, SH-SY5Y, rat brain tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

51 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes