COX1/Cyclooxygenase 1 Recombinant Rabbit Monoclonal Antibody [SC68-05]

About this product

Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase (COX), is the key enzyme in prostaglandin biosynthesis. It converts free arachidonic acid, released from membrane phospholipids at the sn-2 ester binding site by the enzymatic activity of phospholipase A2, to prostaglandin (PG) H2. The reaction involves both cyclooxygenase (dioxygenase) and hydroperoxidase (peroxidase) activity. The cyclooxygenase activity incorporates two oxygen molecules into arachidonic acid or alternate polyunsaturated fatty acid substrates, such as linoleic acid and eicosapentaenoic acid. Metabolism of arachidonic acid forms a labile intermediate peroxide, PGG2, which is reduced to the corresponding alcohol, PGH2, by the enzyme's hydroperoxidase activity. COX-1 promotes the production of the natural mucus lining that protects the inner stomach and contributes to reduced acid secretion and reduced pepsin content. COX-1 is normally present in a variety of areas of the body, including not only the stomach but any site of inflammation.

Specifications

Catalog number

ET1610-98

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

COX 1 antibody COX 3 antibody COX-1 antibody COX1 antibody Cox3 antibody Cyclooxygenase 1 antibody Cyclooxygenase 3, included antibody Cyclooxygenase-1 antibody EC 1.14.99.1 antibody Partial COX1 proteins, included antibody PCOX1 antibody PGG/HS antibody PGH synthase 1 antibody PGH1_HUMAN antibody PGHS-1 antibody PGHS1 antibody PHS 1 antibody PHS1 antibody Prostaglandin G/H synthase 1 antibody Prostaglandin H2 synthase 1 antibody Prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase) antibody Prostaglandin-endoperoxide synthase 1 antibody PTGHS antibody PTGS1 antibody

Abbreviation

COX-1, PGH synthase 1, PGHS-1, PHS 1, PTGS1

Swiss Prot

P23219 Human, P22437 Mouse, Q63921 Rat

Cellular Locus

Microsome membrane, Endoplasmic reticulum membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human COX1 aa 116-159 / 599.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, FC, IP

Positive Control

NIH/3T3 cell lysate, C2C12 cell lysate, L6 cell lysate, A431 cell lysate, Hela, N2A, C2C12, L6, mouse skin tissue, mouse brain tissue, human breast carcinoma tissue, mouse stomach tissue, human skin tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:50-1:1,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 69 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes