Phospho-MSK1 (S376) Recombinant Rabbit Monoclonal Antibody [SN63-05]

About this product

The family of ribosomal S6 kinases (Rsks), designated Rsk-1, Rsk-2 and Rsk-3, have been implicated as important signaling intermediates in response to a broad range of ligand-activated receptor tyrosine kinases. A unique feature common to the three members of the Rsk family is that each possesses two non-identical complete kinase catalytic domains. A related S6 kinase, p70 S6 kinase, functions to phosphorylate the S6 protein on ribosomal 40S subunits. p70 S6 kinase b shares high sequence homology with p70 S6 kinase, except in the carboxy terminus where it contains a proline-rich domain that may be involved in SH3 domain containing protein interactions. MSK1 (also designated RLPK) is related to Rsk and p70 S6 kinase family members and is thought to be structurally similar to Rsk family members, but it may be regulated by distinct mechanisms.

Specifications

Catalog number

ET1611-17

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

90 kDa ribosomal protein S6 kinase 5 antibody EC 2.7.11.1 antibody KS6A5_HUMAN antibody MGC1911 antibody Mitogen and stress activated protein kinase 1 antibody MSPK1 antibody Nuclear Mitogen And Stress Activated Protein Kinase 1 antibody Nuclear mitogen- and stress-activated protein kinase 1 antibody Ribosomal protein S6 kinase 90kD polypeptide 5 antibody Ribosomal protein S6 kinase 90kDa antibody Ribosomal protein S6 kinase 90kDa polypeptide 5 antibody Ribosomal Protein S6 Kinase Alpha 5 antibody Ribosomal protein S6 kinase alpha-5 antibody RLPK antibody RPS6KA5 antibody RSK Like Protein Kinase antibody RSK-like protein kinase antibody RSKL antibody S6K alpha 5 antibody S6K-alpha-5 antibody

Abbreviation

S6K-alpha-5, RSKL, RPS6KA5

Swiss Prot

O75582 Human

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Ser376 of Human MSK1 aa 351-400 / 802.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP

Positive Control

HEK-293 cells treated with 200nM PMA for 30 minutes, human colon tissue, rat bladder tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 90 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes