hnRNP C1+C2 Recombinant Rabbit Monoclonal Antibody [SN0652]

About this product

Heterogeneous nuclear ribonucleoproteins (hnRNPs) constitute a set of polypeptides that contribute to pre-mRNA processing and transport, and also bind heterogeneous nuclear RNA (hnRNA), which are the transcripts produced by RNA polymerase II. hnRNP complexes are the major constituents of the spliceosome and, in particular, the hnRNP A1 protein is one of the major pre-mRNA/mRNA binding proteins and also one of the most abundant proteins in the nucleus. hnRNP A1 and A2/B1 regulate the processing of pre-mRNA by directly antagonizing the association of various splicing factors and by influencing the splice site selection on pre-mRNA. The majority of hnRNP proteins components are localized to the nucleus; however, some shuttle between the nucleus and the cytoplasm. Most hnRNP proteins, in-cluding hnRNP C1 and C2, contain one or more RNA binding domains and are implicated in the processing of pre-mRNA. hnRNPs F and H are largely related factors that preferentially associate with poly (rG) regions on RNA. Isoforms of these proteins are often generated by alternative processing of the pre-mRNA and by posttranslational modifications such as phosphorylation on serines and threonines and methylation of arginines.

Specifications

Catalog number

ET1611-2

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

C1 antibody C2 antibody Heterogeneous nuclear ribonucleoprotein C (C1/C2) antibody Heterogeneous nuclear ribonucleoprotein C antibody Heterogeneous nuclear ribonucleoproteins C1/C2 antibody HNRNP antibody hnRNP C1 / hnRNP C2 antibody hnRNP C1/C2 antibody Hnrnpc antibody HNRPC antibody HNRPC_HUMAN antibody MGC104306 antibody MGC105117 antibody MGC117353 antibody MGC131677 antibody Nuclear ribonucleoprotein particle C1 protein antibody Nuclear ribonucleoprotein particle C2 protein antibody SNRPC antibody

Abbreviation

hnRNP C1/C2, HNRNPC

Swiss Prot

P07910 Human, Q9Z204 Mouse, P17132 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat, Zebrafish

Immunogen

Recombinant protein of Human HNRNPC aa 60-190 / 306.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

Hela cell lysate, HepG2 cell lysate, MCF-7 cell lysate, Hela, MCF-7, B16F1, human breast carcinoma tissue, human kidney tissue, mouse brain tissue, mouse skin tissue, mouse placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;IHC-P: 1:50-1:200;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 34 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes