IKK alpha + IKK beta Recombinant Rabbit Monoclonal Antibody [SN63-02]

About this product

IKK-α is part of the IκB kinase complex that plays an important role in regulating the NF-κB transcription factor. IKK-β is an enzyme that serves as a protein subunit of IκB kinase, which is a component of the cytokine-activated intracellular signaling pathway involved in triggering immune responses. IKK's activity causes activation of a transcription factor known as Nuclear Transcription factor kappa-B or NF-κB. Activated IKK-β phosphorylates a protein called the inhibitor of NF-κB, IκB (IκBα), which binds NF-κB to inhibit its function. IKK-α and IKK-β phosphorylate the IκB proteins, marking them for degradation via ubiquitination and allowing NF-κB transcription factors to go into the nucleus. Once activated, NF-κB transcription factors regulate genes that are implicated in many important cellular processes, including immune response, inflammation, cell death, and cell proliferation.

Specifications

Catalog number

ET1611-23

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CHUK antibody Conserved helix loop helix ubiquitous kinase antibody I kappa B kinase 1 antibody I kappa B kinase 2 antibody I Kappa B kinase alpha antibody I Kappa B kinase beta antibody IkB kinase alpha subunit antibody IkBKA antibody IkBKB antibody IKK a kinase antibody IKK alpha antibody IKK beta antibody IKK1 antibody IKK2 antibody IKKA antibody IKKB antibody IMD15 antibody Inhibitor of kappa light polypeptide gene enhancer in B cells kinase beta antibody Inhibitor of nuclear factor kappa-B kinase subunit alpha antibody Inhibitor of nuclear factor kappa-B kinase subunit beta antibody NFKBIKA antibody NFKBIKB antibody Nuclear factor NF kappa B inhibitor kinase beta antibody Nuclear factor NFkappaB inhibitor kinase alpha antibody TCF 16 antibody TCF16 antibody Transcription factor 16 antibody

Abbreviation

I-kappa-B kinase alpha, IKK-A, IKK-alpha, IkBKA, IkappaB kinase, IKK1, NFKBIKA, TCF-16, CHUK, I-kappa-B-kinase beta, IKK-B, IKK-beta, IkBKB, IKK2, NFKBIKB, IKBKB

Swiss Prot

O14920 Human, O15111 Human, O88351 Mouse, Q60680 Mouse, Q9QY78 Rat

Cellular Locus

Cytoplasm, Nucleus, Membrane raft.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human IKK beta aa 450-652 / 756.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IP

Positive Control

HeLa cell lysate, 293T cell lysate, Daudi cell lysate, A431, NIH/3T3, C6.

Concentration

1 mg/mL

Dilution

WB: 1:2,000 ;IF-Cell: 1:100-1:500 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 87 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes