Phospho-c-Myc (T58) Recombinant Rabbit Monoclonal Antibody [SN60-01]

About this product

Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc. In cancer, c-myc is often constitutively (persistently) expressed. This leads to the increased expression of many genes, some of which are involved in cell proliferation, contributing to the formation of cancer. A common human translocation involving c-myc is critical to the development of most cases of Burkitt lymphoma. Constitutive upregulation of Myc genes have also been observed in carcinoma of the cervix, colon, breast, lung and stomach. Myc is thus viewed as a promising target for anti-cancer drugs. Unfortunately, Myc possesses several features that render it undruggable such that any anti-cancer drugs for Myc dysregulation will require acting on the protein indirectly, i.e. targeting the mRNA for the protein rather than a small molecule that targets the protein itself.

Specifications

Catalog number

ET1611-24

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Avian myelocytomatosis viral oncogene homolog antibody bHLHe39 antibody c Myc antibody Class E basic helix-loop-helix protein 39 antibody MRTL antibody Myc antibody Myc protein antibody Myc proto oncogene protein antibody Myc proto-oncogene protein antibody myc related translation/localization regulatory factor antibody MYC_HUMAN antibody Myc2 antibody MYCC antibody Niard antibody Nird antibody Proto-oncogene c-Myc antibody Transcription factor p64 antibody v myc avian myelocytomatosis viral oncogene homolog antibody v myc myelocytomatosis viral oncogene homolog antibody

Abbreviation

bHLHe39, MYC

Swiss Prot

P01106 Human, P01108 Mouse, P09416 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Thr58 of Human Myc (P01106-1).

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, FC, IHC-P

Positive Control

HCT 116 cell lysate, HCT 116 treated with 25μM MG-132 for 4 hours cell lysate, NIH/3T3 treated with 10μM MG-132 for 8 hours cell lysate, Hela, SKOV-3, human kidney tissue, MCF-7, human skin tissue, mouse skin tissue, rat skin tissue, EL4 cell lysate, EL4 treated with 25μM MG-132 for 4 hours cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;FC: 1:50-1:100 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:500

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 49 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes