BTK Recombinant Rabbit Monoclonal Antibody [SN69-07]

About this product

The Tec family of non-receptor tyrosine kinases is composed of six proteins designated Tec, Emt (also known as Itk or Tsk), Btk (previously known as Atk, BPK or Emb), Bmx, Txk (also known as Rlk) and Dsrc28C. All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini. Four alternatively spliced forms of Tec are found to be expressed broadly in cells of hematopoietic lineage and hepatocytes. The Emt gene product associates with CD28 and becomes activated subsequent to CD28 ligation. Btk is necessary for proper B cell development, and mutations in the gene encoding Btk have been associated with families suffering from X-linked agammaglobulinemia, also referred to as Bruton's disease. The Bmx protein shares a high degree of homology with Btk and seems to be expressed at highest levels in the heart. Txk expression is T cell-specific, while expression of the Drosophila Tec homolog, Dsrc28C, is developmentally regulated.

Specifications

Catalog number

ET1611-4

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Agammaglobulinaemia tyrosine kinase antibody AGMX 1 antibody AGMX1 antibody AT antibody ATK antibody B cell progenitor kinase antibody B-cell progenitor kinase antibody BPK antibody Bruton agammaglobulinemia tyrosine kinase antibody Bruton tyrosine kinase antibody Bruton’s Tyrosine Kinase antibody Btk antibody BTK_HUMAN antibody dominant-negative kinase-deficient Brutons tyrosine kinase antibody IMD 1 antibody IMD1 antibody MGC126261 antibody MGC126262 antibody OTTHUMP00000063593 antibody PSCTK 1 antibody PSCTK1 antibody truncated Bruton agammaglobulinemia tyrosine kinase antibody Tyrosine protein kinase BTK antibody Tyrosine-protein kinase BTK antibody tyrosine-protein kinase BTK isoform (lacking exon 14 antibody XLA antibody

Abbreviation

ATK, BPK, BTK, AGMX1, ATK, BPK

Swiss Prot

Q06187 Human

Cellular Locus

Cell membrane, Cytoplasm, Membrane, Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human BTK aa 610-659 / 659.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP

Positive Control

Daudi cell lysate, Raji cell lysate, U937 cell lysate, U2932, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IHC-P: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 76 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes