PARK7/DJ1 Recombinant Rabbit Monoclonal Antibody [SN07-21]

About this product

PARK7/DJ1 is a ubiquitously expressed protein involved in various cellular processes including cell proliferation, RNA-binding, and oxidative stress. The protein has been found to colocalize within a subset of pathologic tau inclusions in a diverse group of neurodegenerative disorders known as tauopathies. Defects in PARK7/DJ1 are the cause of autosomal recessive early-onset Parkinson's disease 7 (PARK7). Parkinson's disease (PD) is a complex, multifactorial disorder that typically manifests after the age of 50 years. The disease is characterized by bradykinesia, resting tremor, muscular rigidity and postural instability. The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK7 is characterized by onset before 40 years and slow progression. It has also been suggested that PARK7/DJ1 is a mitogen dependent oncogene product involved in Ras related signal transduction pathways.

Specifications

Catalog number

ET1611-45

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CAP1 antibody DJ-1 antibody DJ1 antibody DJ1 protein antibody Epididymis secretory sperm binding protein Li 67p antibody FLJ27376 antibody FLJ34360 antibody FLJ92274 antibody HEL S 67p antibody Oncogene DJ1 antibody OTTHUMP00000001348 antibody OTTHUMP00000001349 antibody OTTHUMP00000001350 antibody OTTHUMP00000001351 antibody PARK7 antibody PARK7_HUMAN antibody Parkinson disease (autosomal recessive, early onset) 7 antibody Parkinson disease protein 7 antibody Parkinson protein 7 antibody Protein DJ-1 antibody SP22 antibody

Abbreviation

DJ-1, PARK7

Swiss Prot

Q99497 Human, Q99LX0 Mouse, O88767 Rat

Cellular Locus

Cell membrane, Cytoplasm, Endoplasmic reticulum, Membrane, Mitochondrion, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PARK7 aa 11-60 / 189.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HeLa cell lysate, SH-SY5Y cell lysate, HepG2 cell lysate, mouse brain tissue lysate, rat brain tissue lysate, HeLa, human breast tissue, human kidney tissue, human pancreas tissue, mouse prostate tissue, mouse pancreas tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:100-1:500 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 20 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes