Cytokeratin 1 Recombinant Rabbit Monoclonal Antibody [SN72-08]

About this product

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue. Cytokeratins constitute up to 85% of a mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10-nm diameter filaments. Cytokeratins are useful markers of tissue differentiation, and they aid in the characterization of malignant tumors. Cytokeratin 1 is highly expressed in several malignancies including epithelioid hemangioendohtheliomas, angiosarcomas, schwannomas, epithelioid sarcomas and synodal sarcomas. The gene encoding human Cytokeratin 1 maps to chromosome 12q13.13. Mutations in the gene encoding human Cytokeratin 1 lead to abnormal filament associations and epidermolytic hyperkeratosis.

Specifications

Catalog number

ET1611-46

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

67 kDa cytokeratin antibody CK-1 antibody CK1 antibody Cytokeratin-1 antibody Cytokeratin1 antibody EHK antibody EHK1 antibody Epidermolytic hyperkeratosis 1 antibody EPPK antibody Hair alpha protein antibody K1 antibody K2C1_HUMAN antibody Keratin antibody Keratin type II cytoskeletal 1 antibody Keratin-1 antibody Keratin1 antibody KRT 1 antibody Krt1 antibody KRT1A antibody NEPPK antibody type II cytoskeletal 1 antibody Type II keratin Kb1 antibody Type-II keratin Kb1 antibody

Abbreviation

CK-1, K1, KRT1

Swiss Prot

P04264 Human, P04104 Mouse, Q6IMF3 Rat

Cellular Locus

Cell membrane, Intermediate filament, Keratin, Membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within mouse Cytokeratin 1 aa 586-637 / 637.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IF-Tissue

Positive Control

Hela cell lysate, 293T cell lysate, human skin tissue, rat skin tissue, mouse skin.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:400-1:1,500 ;IF-Tissue: 1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 66 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes