CD13 Recombinant Rabbit Monoclonal Antibody [SN71-04]

About this product

CD13, or aminopeptidase N, is a type II transmembrane glycoprotein that is expressed on most cells of Myeloid origin, including monocytes, basophils, eosinophils, neutrophils and Myeloid leukemias. CD13 is also found on certain epithelial cells, fibroblasts and osteoclasts. CD13 acts as a zinc-binding metalloprotease that plays a role in digestion and may function in the inactivation of some regulatory peptides such as enkephalins. CD13 may play a role in the invasion of cancer cells by enhancing their invasive capacity and metastatic behavior. The activity of CD13 can be inactivated using specific inhibitors that evoke apoptosis of CD13-positive cancer cells. Basic fibroblast growth factor (bFGF) expression upregulates CD13 expression in human melanoma cells by activating both the Myeloid and the epithelial CD13 promoter.

Specifications

Catalog number

ET1611-61

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Alanyl (membrane) aminopeptidase antibody Alanyl aminopeptidase antibody Aminopeptidase M antibody Aminopeptidase N antibody AMPN_HUMAN antibody ANPEP antibody AP M antibody AP N antibody AP-M antibody AP-N antibody APN antibody CD 13 antibody CD13 antibody CD13 antigen antibody gp150 antibody hAPN antibody LAP 1 antibody LAP1 antibody Microsomal aminopeptidase antibody Myeloid plasma membrane glycoprotein CD13 antibody p150 antibody PEPN antibody

Abbreviation

AP-N, hAPN, AP-M, ANPEP

Swiss Prot

P15144 Human, P97449 Mouse, P15684 Rat

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human CD13 aa 401-450 / 967.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IHC-P, IP

Positive Control

Mouse kidney tissue lysate, THP-1 cell lysate, human kidney tissue lysate, Hela, HepG2, PANC-1, human tonsil tissue, human liver tissue, human breast tissue, human kidney tissue, mouse pancreas tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:100-1:500 ;IHC-P: 1:100-1:500 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 110 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes