TMS1 Recombinant Rabbit Monoclonal Antibody [SN07-10]

About this product

The death domain (DD) superfamily of proteins share one or more of the following domains: the DD, DED (death-effector domain), CARD (caspase-recruitment domain) and PYD (Pyrin domain). Each of these domains is characterized by a canonical death domain fold, which consists of a bundle of five or six antiparallel α-helices. As their names suggest, these domains play prominent roles in programmed cell death. Caspase-associated recruitment domains (CARDs) mediate the interaction between adaptor proteins such as Apaf-1 and the proform of caspases (e.g., CASP9) participating in apoptosis. ASC (apoptosis-associated speck-like protein containing a CARD, also known as TMS1or PYCARD) is a member of the CARD-containing adaptor protein family. ASC is a 195 amino acid protein, containing a N-terminal Pyrin-like domain (PYD) and an 87 residue C-terminal CARD. This motif is characteristic of numerous proteins involved in apoptotic signaling. ASC2 (apoptosis-associated speck-like protein containing a CARD 2), also known as Pyrin-only protein 1 or PADD-only protein 1, is an 89 amino acid member of the DD superfamily that contains one Pyrin domain. Localized to the cytoplasm, ASC2 interacts with ASC to modulate NF-κB and pro-caspase-1 regulation.

Specifications

Catalog number

ET1611-62

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Apoptosis associated speck like protein containing a CARD antibody Apoptosis-associated speck-like protein containing a CARD antibody ASC antibody ASC_HUMAN antibody CARD 5 antibody CARD5 antibody Caspase recruitment domain containing protein 5 antibody Caspase recruitment domain protein 5 antibody Caspase recruitment domain-containing protein 5 antibody hASC antibody MGC10332 antibody PYCARD antibody PYD and CARD domain containing antibody PYD and CARD domain containing protein antibody PYD and CARD domain-containing protein antibody Target of methylation induced silencing 1 antibody Target of methylation-induced silencing 1 antibody TMS 1 antibody TMS antibody TMS1 antibody

Abbreviation

hASC, PYCARD, ASC, CARD5

Swiss Prot

Q9ULZ3 Human

Cellular Locus

Cytoplasm, Endoplasmic reticulum, Golgi apparatus, Inflammasome, Membrane, Mitochondrion, Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human TMS1 aa 121-170 / 195.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

THP-1 cell lysates, THP-1, human skin tissue, human lymph nodes tissue, human spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:50-1:400 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 22 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes