CCR2 Recombinant Rabbit Monoclonal Antibody [SN707]

About this product

Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion (Probable). Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression; signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury.

Specifications

Catalog number

ET1611-65

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

C C chemokine receptor type 2 antibody C C CKR 2 antibody C-C chemokine receptor type 2 antibody C-C CKR-2 antibody CC chemokine receptor type 2 antibody CC CKR 2 antibody CC-CKR-2 antibody CCCKR2 antibody CCR 2 antibody CCR-2 antibody CCR1L antibody CCR2 antibody CCR2_HUMAN antibody CCR2A antibody CCR2B antibody CCR5L antibody CD192 antibody CD192 antigen antibody Chemokine C C motif receptor 2 antibody Chemokine CC Motif Receptor 2 antibody CKR 2 antibody CKR2 antibody CKR2A antibody CKR2B antibody CMKBR2 antibody MCP 1 R antibody MCP-1-R antibody MCP1 RECEPTOR antibody MCP1R antibody Monocyte chemoattractant protein 1 receptor antibody Monocyte Chemotactic Protein 1 Receptor antibody Monocyte Chemotactic Protein 1 Receptor antibody

Abbreviation

C-C CKR-2, CC-CKR-2, CCR-2, CCR2, MCP-1-R, CCR2, CMKBR2

Swiss Prot

P41597 Human, P51683 Mouse

Cellular Locus

Cell membrane.

Host

Rabbit

Species Reactivity

Human, Mouse

Immunogen

Synthetic peptide within N-terminal human CCR2.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P, IP, FC

Positive Control

Mouse spleen tissue lysate, THP-1 cell lysate, human tonsil tissue, human breast carcinoma tissue, human esophagus tissue, THP-1.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:500 ;FC: 1:500-1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 42 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes