FANCD2 Recombinant Rabbit Monoclonal Antibody [SN73-08]

About this product

Fanconi anemia (FA) is an autosomal recessive disorder character-ized by bone marrow failure, birth defects and chromosomal instability. At the cellular level, FA is characterized by spontaneous chromosomal breakage and a unique hypersensitivity to DNA cross-linking agents. At least 8 complementation groups (A-G) have been identified and 6 FA genes (for subtypes A, C, D2, E, F and G) have been cloned. The FA proteins lack sequence homologies or motifs that could point to a molecular function. Phosphorylation of FANC (Fanconi anemia complementation group) proteins are thought to be important for the function of the FA pathway. Several FA proteins, including FANCA, FANCC, FANCF, and FANCG, interact in a nuclear complex, and this complex is required for the activation (monoubiquitination) of the downstream FANCD2 protein. When monoubiquitinated, the FANCD2 protein co-localizes with the breast cancer susceptibility protein BRCA1 in DNA damage induced foci. In male meiosis, FANCD2 also co-localizes with BRCA1 at synaptonemal complexes. The human FANCD2 gene maps to chromosome 3p25.3, contains 44 exons and encodes a 1,451-amino acid nuclear protein that exists as 2 protein isoforms.

Specifications

Catalog number

ET1611-67

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

DKFZp762A223 antibody FA 4 antibody FA D2 antibody FA4 antibody FAC D2 antibody FACD 2 antibody FACD antibody FACD2 antibody FACD2_HUMAN antibody FAD antibody FAD2 antibody FANC D2 antibody FANCD 2 antibody FANCD antibody FANCD2 antibody FANCONI ANEMIA COMPLEMENTATION GROUP D antibody Fanconi anemia complementation group D2 antibody Fanconi anemia group D2 protein antibody FANCONI PANCYTOPENIA TYPE 4 antibody FLJ23826 antibody OTTHUMP00000158853 antibody OTTHUMP00000207925 antibody Protein FACD2 antibody Type 4 Fanconi pancytopenia antibody

Abbreviation

FANCD2, Protein FACD2

Swiss Prot

Q9BXW9 Human, Q80V62 Mouse, Q6IV68 Rat

Cellular Locus

Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human FANCD2 aa 191-240 / 1,451.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

Daudi cell lysate, K562 cell lysate, SW480, Hela, MCF-7, mouse testis tissue, rat stomach tissue, rat testis tissue, mouse stomach tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;IHC-P: 1:50-1:200;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 164 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes