Cytokeratin 6 Recombinant Rabbit Monoclonal Antibody [SN71-07]

About this product

Cytokeratins comprise a diverse group of intermediate filament proteins (IFPs) that are expressed as pairs in both keratinized and non-keratinized epithelial tissue, where they constitute up to 85% of mature keratinocytes in the vertebrate epidermis. Cytokeratins play a critical role in differentiation and tissue specialization and function to maintain the overall structural integrity of epithelial cells. The alpha-helical coiled-coil dimers associate laterally end-to-end to form 10 nm diameter filaments. Cytokeratins, which are useful markers of tissue differentiation, also aid in the characterization of malignant tumors. IL-1 and TNFα induce transcription of cytokeratin 6 in epidermal keratinocytes via the C/EBP β transcription factor. In humans, multiple isoforms of cytokeratin 6 (6A-6F), encoded by several highly homologous genes, have distinct tissue expression patterns, and cytokeratin 6A is the dominant form in epithelial tissue. The gene encoding human cytokeratin 6A maps to chromosome 12q13, and mutations in this gene are linked to several inheritable hair and skin pathologies.

Specifications

Catalog number

ET1611-70

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CK6 antibody CK 6A antibody CK 6B antibody CK 6C antibody CK 6D antibody CK 6E antibody CK-6B antibody CK-6C antibody CK-6E antibody Cytokeratin 6a antibody Cytokeratin 6B antibody Cytokeratin 6C antibody Cytokeratin 6D antibody Cytokeratin 6E antibody Cytokeratin-6B antibody Cytokeratin-6C antibody Cytokeratin-6E antibody K2C6C_HUMAN antibody K6a keratin antibody K6b keratin antibody K6C antibody K6c keratin antibody K6d keratin antibody K6e keratin antibody Keratin antibody Keratin K6h antibody Keratin type II cytoskeletal 6A antibody Keratin type II cytoskeletal 6B antibody Keratin type II cytoskeletal 6C antibody Keratin type II cytoskeletal 6D antibody Keratin type II cytoskeletal 6E antibody Keratin-6C antibody KRT6A antibody KRT6B antibody KRT6C antibody KRT6D antibody KRT6E antibody type II cytoskeletal 6C antibody Type-II keratin Kb12 antibody

Abbreviation

CK-6A, CK-6D, K6A, KRT6A, CK-6B, K6B, KRT6B, CK-6C, CK-6E, K6C, KRT6C

Swiss Prot

P02538 Human, P04259 Human, P48668 Human, Q4FZU2 Rat

Cellular Locus

Keratin filament, cytosol, extracellular exosome, nucleus, membrane.

Host

Rabbit

Species Reactivity

Human, Rat

Immunogen

Recombinant protein within Human Cytokeratin 6 aa 1-118 / 564.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

A431 cell lysate, human skin tissue lysate, A431, rat skin tissue, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 60 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes