MUC16 Recombinant Rabbit Monoclonal Antibody [SN69-06]

About this product

The mucins are a family of highly glycosylated, secreted proteins with a basic structure consisting of a variable number of tandem repeats (VNTRs). Membrane-associated and secretory Mucins are high molecular weight glycoproteins of the glycocalyx (polysaccharide biofilm) that protects mucosal epithelium from particulate matter and microorganisms. Epithelial Mucins are large, secreted and cell surface glycoproteins crucial for adhesion modulation, signaling and epithelial cell protection. The number of repeats is highly polymorphic and varies among different alleles. The Mucin family consists of Mucins 1-4, Mucin 5 (AC and B), Mucins 6-8, Mucins 11-13 and Mucins 15-17. The Mucin 16 protein (also commonly referred to as CA125), encoded for by the gene MUC16, is a very high molecular weight tumor antigen consisting of three domains: a carboxy terminal domain, an extracellular domain and an amino terminal domain. Mucin 16, an ovarian cancer-associated antigen, is used as a marker to monitor the progress of epithelial ovarian cancer. It is a hydrophilic membrane-associated protein that may be involved in vitamin A functions.

Specifications

Catalog number

ET1611-74

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CA 125 antibody CA-125 antibody CA125 antibody CA125 ovarian cancer antigen antibody Cancer antigen 125 antibody FLJ14303 antibody MUC 16 antibody MUC-16 antibody MUC16 antibody MUC16_HUMAN antibody Mucin 16 antibody Mucin 16 cell surface associated antibody Mucin-16 antibody Mucin16 antibody Ovarian cancer related tumor marker CA125 antibody Ovarian cancer-related tumor marker CA125 antibody Ovarian carcinoma antigen CA125 antibody hide

Abbreviation

MUC-16, CA-125, MUC16

Swiss Prot

Q8WXI7 Human

Cellular Locus

Cell membrane, Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human MUC16 aa 12331-12339 / 14,507.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

Hela, HepG2, SW480, human endometrium tissue, human ovarian carcinoma tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:100-1:500 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 1519 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes