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![Retinoic Acid Receptor alpha Recombinant Rabbit Monoclonal Antibody [SN0725] — image 1 of 2](https://cdn.genprice.uk/products/992/68dd1c8d061270361ea8218b/imageurl/et1611-77.webp)
Product details
Catalog number ET1611-77
Price for ET1611-77
Size / count 100 µL
Retinoids (RA) are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. RAs activate the retinoic acid receptor (RAR) and retinoid X receptor (RXR) nuclear transcription factor families. Most retinoid forms activate RAR family members, whereas RXR family members are activated by 9-cis-RA only. RAR family members, which include RARα, RARβ and RARγ, have a high affinity for all transretinoic acids and belong to the same class of nuclear transcription factors as thyroid hormone receptors, vitamin D3 receptor and ecdysone receptor. RAR isoforms are expressed in distinct patterns throughout development and in the mature organism. The human RARα gene maps to chromosome 17 and is implicated in the chromosomal translocation associated with acute promyelocytic leukemia (APL-M3). Specifically, the RARα gene is fused with the promyelocytic leukemia (PML) gene, which encodes the fusion protein PML/RARα. The PML/RARα fusion protein inhibits PML-dependent apoptotic pathways and halts myeloid differentiation at the promyelocytic stage.
The catalog number for Retinoic Acid Receptor alpha Recombinant Rabbit Monoclonal Antibody [SN0725] is ET1611-77.
Retinoic Acid Receptor alpha Recombinant Rabbit Monoclonal Antibody [SN0725] is available in the following size(s): 100 µL.
Retinoic Acid Receptor alpha Recombinant Rabbit Monoclonal Antibody [SN0725] is currently made to order / not held in immediate stock. Contact us for lead time.
Retinoids (RA) are metabolites of vitamin A (retinol) that are important signaling molecules during vertebrate development and tissue differentiation. RAs activate the retinoic acid receptor (RAR) and retinoid X receptor (RXR) nuclear transcription factor families. Most retinoid forms activate RAR f
As a consumer, you have a 14-day right of withdrawal from receipt under EU consumer protection law, submitted via our withdrawal/cancellation request form. Note this applies to unused, undamaged products, and doesn’t override the expiry/storage conditions on performance-based claims.
Endotoxin testing status is noted on the datasheet where applicable, particularly for recombinant proteins intended for cell-based or functional assays. If this isn’t listed and you need confirmation, contact support with the catalogue number.
Additional data may be available on request. Contact our technical support team with the catalogue number and we’ll check what supporting documentation the supplier can provide.
