Bcl10 Recombinant Rabbit Monoclonal Antibody [SN74-04]

About this product

Bcl10, also designated CIPER, c-CARMEN and mE10, was first identified as a gene truncated or mutated in MALT B cell lymphomas and other tumor types. Bcl10 is homologous to the equine herpesvirus-2 E10 gene and, like E10, it contains an N-terminal caspase recruitment domain (CARD). Expression of Bcl10 has been shown to induce NFκB activation in a NIK-dependent pathway, and research indicates that the CARD domain is essential for this activation; although in a separate study, Bcl10 by itself did not induce JNK or NFκB activation. Overexpression of Bcl10 has been shown to induce apoptosis in a manner dependent on CARD-mediated oligomerization. Bcl10 has also been shown to play a role in processing of caspase-9 to its active dimer. Other studies have shown that Bcl10 is not mutated in many human tumors and lymphomas.

Specifications

Catalog number

ET1611-79

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AI132454 antibody B cell CLL/lymphoma 10 antibody B cell lymphoma/leukemia10 antibody B-cell CLL/lymphoma 10 antibody B-cell leukemia/lymphoma 10 antibody B-cell lymphoma/leukemia 10 antibody Bcl 10 antibody Bcl-10 antibody Bcl10 antibody BCL10_HUMAN antibody c E10 antibody c-E10 antibody C81403 antibody CARD containing apoptotic signaling protein antibody CARD containing molecule enhancing NF kappa B antibody CARD containing molecule enhancing NF kB antibody CARD containing molecule enhancing NF-kB antibody CARD containing molecule enhancing NFkB antibody CARD containing proapoptotic protein antibody CARD like apoptotic protein antibody CARD-containing apoptotic signaling protein antibody CARD-containing molecule enhancing NF-kappa-B antibody CARD-containing proapoptotic protein antibody CARD-like apoptotic protein antibody CARMEN antibody Caspase recruiting domain containing protein antibody caspase-recruiting domain-containing protein antibody cCARMEN antibody cE 10 antibody cE10 antibody CED 3/ICH 1 prodomain homologous E10 like regulator antibody CED-3/ICH-1 prodomain homologous E10-like regulator antibody CED3/ICH1 prodomain homologous E10 like regulator antibody Cellular E10 antibody Cellular homolog of vCARMEN antibody Cellular-E10 antibody CIPER antibody CLAP antibody hCLAP antibody Mammalian CARD containing adapter molecule E10 antibody Mammalian CARD-containing adapter molecule E10 antibody mE 10 antibody mE10 antibody R-RCD1 antibody

Abbreviation

Bcl-10, hCLAP, CIPER, cCARMEN, c-E10, mE10, BCL10

Swiss Prot

O95999 Human

Cellular Locus

Cytoplasm, Membrane raft.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Bcl10 aa 198-233 / 233.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

HUVEC cell lysate, A549 cell lysate, Jurkat cell lysate, MCF-7, SW480, human tonsil tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 26 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes