Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13] — image 1 of 3

Product details

Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13]

Catalog number ET1611-90

Price for ET1611-90

Size / count 100 µL

About this product

The insulin receptor (IR) is a heterodimeric protein complex that has an intracellular β subunit and an extracellular α subunit, which is disulfide- linked to a transmembrane segment. The insulin ligand binds to the IR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to IR induces phosphorylation of intracellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. The human insulin receptor gene maps to chromosome 19p13.3-p13.2 and encodes a 1382 amino acid protein that cleaves to form α and β subunits. Type 1 diabetes is an auto-immune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells. Type 2 diabetes is a condition where cells become resistant to insulin action.

Specifications

Catalog number: ET1611-90
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CD220 antibody HHF5 antibody HIR A antibody INSR antibody Insulin receptor antibody Insulin receptor subunit alpha antibody IR antibody
Abbreviation: IR, INSR
Swiss Prot: P06213 Human, P15208 Mouse, P15127 Rat
Cellular Locus: Cell membrane.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within human Insulin receptor aa 930-970.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC
Positive Control: MCF-7 cell lysate, 293 cell lysate, mouse skeletal muscle tissue lysates, HepG2, LO2, RH-35, PANC-1.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500 ;IHC: 1:1,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 156 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13]?

The catalog number for Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13] is ET1611-90.

What sizes are available for Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13]?

Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13] is available in the following size(s): 100 µL.

Is Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13] in stock?

Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Insulin Receptor Beta Recombinant Rabbit Monoclonal Antibody [SN20-13] used for?

What is the recommended positive control for this assay?

A recommended positive control, where one is specified by the manufacturer, is listed on the datasheet or in the assay protocol.

How should this product be stored?

Storage conditions depend on the specific reagent and are listed on the product datasheet, with most antibodies and proteins requiring -20°C unless stated otherwise. It is your responsibility to store the product correctly immediately upon receipt; damage from improper storage after delivery is not eligible for replacement.

Is this product animal-origin-free?

Animal-origin-free status, where applicable, is noted on the datasheet under formulation details.