Ret Recombinant Rabbit Monoclonal Antibody [SN20-28]

About this product

The Ret proto-oncogene (c-Ret) is a receptor tyrosine kinase that functions as a multicomponent receptor complex in conjunction with other membrane-bound, ligand-binding GDNF family receptors. Ligands that bind the Ret receptor include the glial cell line-derived neurotrophic factor (GDNF) and its congeners neurturin, persephin, and artemin. Research studies have shown that alterations in the corresponding RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung’s disease. The Tyr905 residue located in the Ret kinase domain plays a crucial role in Ret catalytic and biological activity. Substitution of Phe for Tyr at position 905 dramatically inhibits Ret autophosphorylation activity.

Specifications

Catalog number

ET1611-98

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

C ret antibody Cadherin family member 12 antibody Cadherin related family member 16 antibody CDHF 12 antibody CDHF12 antibody CDHR16 antibody ELKS Fusion gene antibody HSCR 1 antibody HSCR1 antibody Hydroxyaryl protein kinase antibody MEN2A antibody MEN2B antibody MTC 1 antibody MTC1 antibody Multiple endocrine neoplasia and medullary thyroid carcinoma 1 antibody Oncogene RET antibody Proto oncogene tyrosine protein kinase receptor ret antibody Proto-oncogene c-Ret antibody Proto-oncogene tyrosine-protein kinase receptor ret antibody PTC antibody RET antibody RET ELE1 antibody Ret Proto oncogene antibody RET transforming sequence antibody RET_HUMAN antibody RET51 antibody RET9 antibody tyrosine-protein kinase receptor ret antibody

Abbreviation

RET

Swiss Prot

P07949 Human, P35546 Mouse, G3V9H8 Rat

Cellular Locus

Cell membrane, Endosome membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human Ret aa 1,065-1,114 / 1,114.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

MCF-7 cell lysates, AGS, MCF-7, SW480, human prostate tissue, mouse testis tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:100-1:500 ;IF-Tissue: 1:100-1:500 ;IHC-P: 1:500 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

124 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes