S100A4 Recombinant Rabbit Monoclonal Antibody [SD200-08]

About this product

Fibroblast-specific protein 1 (FSP1, also called S100A4) is considered a marker of fibroblasts in different organs undergoing tissue remodeling and is used to identify fibroblasts derived from EMT in several organs including the liver. The Mts1 gene encodes a small acidic Ca2+-binding protein, Mts1 (also designated S100A4, calvasculin or metastasin). Mts1 belongs to the S100 family of small Ca2+-binding proteins and is expressed in a cell-specific manner. Mts1 protein is involved in tumor progression and metastasis, and also has a significant stimulatory effect on angiogenesis. The level of Mts1 protein in serum increases with aging, suggesting that Mts1 may play a role in the ind-uction of tumor progression via stimulation of angiogenesis. In addition, Mts1 cooperates with p53 in apoptosis induction by binding to the C-term-inal regulatory domain of p53 to inhibit the DNA binding activity of p53. The ability of Mts1 to enhance p53-dependent apoptosis may accelerate the loss of p53 function in tumors. Thus, Mts1 can contribute to the development of a more aggressive phenotype during tumor progression.

Specifications

Catalog number

ET1612-13

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

Yes

CAS Number

9000-83-3

Product Name Alternative

18A2 antibody 42A antibody calcium Placental protein antibody Calvasculin antibody CAPL antibody Fibroblast specific protein 1 (FSP1) antibody Fibroblast specific protein 1 antibody Fibroblast specific protein antibody FSP1 antibody Leukemia multidrug resistance associated protein antibody Malignant transformation suppression 1 (MTS1) antibody Malignant transformation suppression 1 antibody Metastasin antibody MTS1 antibody OTTHUMP00000015467 antibody OTTHUMP00000015468 antibody P9KA antibody PEL98 antibody Placental calcium-binding protein antibody Protein Mts1 antibody Protein S100 A4 antibody Protein S100-A4 antibody S100 calcium binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog) antibody S100 calcium binding protein A4 antibody S100 calcium-binding protein A4 antibody S100a4 antibody S10A4_HUMAN antibody

Abbreviation

S100A4

Swiss Prot

P26447 Human, P07091 Mouse, P05942 Rat

Cellular Locus

Extracellular space, nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human S100A4 aa 1-101 / 101.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HeLa cell lysate, A549 cell lysate, NIH/3T3, Hela, MCF-7, human tonsil tissue, human lung tissue, human stomach carcinoma tissue, mouse lung tissue, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 12 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes