MEK3 Recombinant Rabbit Monoclonal Antibody [SD20-93]

About this product

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersinia pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.

Specifications

Catalog number

ET1612-2

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AW212142 antibody dual specificity mitogen activated protein kinase kinase 3 antibody Dual specificity mitogen-activated protein kinase kinase 3 antibody MAP kinase kinase 3 antibody map2k3 antibody MAPK ERK kinase 3 antibody MAPK/ERK kinase 3 antibody MAPKK 3 antibody MAPKK3 antibody MEK 3 antibody MEK3 antibody Mitogen activated protein kinase kinase 3 antibody MKK 3 antibody MKK3 antibody mMKK3b antibody MP2K3_HUMAN antibody PRKMK 3 antibody PRKMK3 antibody protein kinase, mitogen-activated, kinase 3 antibody SAPK kinase 2 antibody SAPKK 2 antibody SAPKK2 antibody Stress activated protein kinase kinase 2 antibody

Abbreviation

MAP kinase kinase 3, MAPKK 3, MEK 3, SAPK kinase 2, SAPKK-2, SAPKK2, MAP2K3

Swiss Prot

P46734 Human, O09110 Mouse

Cellular Locus

Cytosol, nucleoplasm, membrane.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within human MEK3 aa 101-347/347.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

Hela cell lysates, Hela, human liver tissue, human breast carcinoma tissue, mouse spleen tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;FC: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 39 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes