PDPK1 Recombinant Rabbit Monoclonal Antibody [SD204-9]

About this product

PDPK1 (3-phosphoinositide dependent protein kinase 1), also known as PDK1, PDPK2, PDPK2P or PRO0461, is 556 amino acid ubiquitously expressed protein that localizes to the cell membrane, cytoplasm and nucleus. Acting as a master kinase, PDPK1 phosphorylates and activates a subgroup of the AGC family of protein kinases. PDPK1 is involved in mediating signal transduction for controlling proliferation, survival, and growth of developing pancreatic beta cells, regulating Ca2+ uptake and Ca2+-activated K+ channels of mast cells, regulation of chemotaxis and motility of vascular endothelial cells, cardiac homeostasis, and thymocyte development. Belonging to the protein kinase superfamily, PDPK1 contains a PH domain, which play an essential role in homodimerization, localization and nuclear import of PDPK1, and a protein kinase domain. PDPK1 exists as five alternatively spliced isoforms and is encoded by a gene located on human chromosome 16p13.3.

Specifications

Catalog number

ET1612-27

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

3 phosphoinositide dependent protein kinase 1 antibody 3-phosphoinositide-dependent protein kinase 1 antibody hPDK 1 antibody hPDK1 antibody MGC20087 antibody MGC35290 antibody OTTHUMP00000159109 antibody OTTHUMP00000159110 antibody OTTHUMP00000174525 antibody PDK1 antibody Pdpk1 antibody PDPK1_HUMAN antibody PDPK2 antibody PDPK2P antibody PkB kinase antibody PkB kinase like gene 1 antibody PkB like 1 antibody PRO0461 antibody Protein kinase antibody

Abbreviation

hPDK1

Swiss Prot

O15530 Human, Q9Z2A0 Mouse, O55173 Rat

Cellular Locus

Cell membrane, Nucleus, Cytoplasm, focal adhesion.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human PDPK1 aa 1-50 / 556.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P

Positive Control

293T cell lysate, PC-12 cell lysate, HL-60 cell lysate, Hela, MCF-7, SW480, human breast carcinoma tissue, mouse kidney tissue, human colon carcinoma tissue, human kidney tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

63 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes