Caspase-5 Recombinant Rabbit Monoclonal Antibody [SD203-2]

About this product

Caspases are cysteine proteases which play important roles in the activation of cytokines and in apoptosis. The ICE subfamily of caspases comprises peptides closely related to caspase-1, which promotes maturation of interleukin 1β (IL-1β) and interleukin-18 (IL-18) by proteolytic cleavage of precursor forms to generate biologically active peptides. Both caspase-4 and caspase-5 are members of the caspase-1 subfamily, and are more closely related to each other than to other homologues. Caspase-5 (also designated ICErel-III, TY, ICH-3 and caspase-12 in mouse), can cleave its own precursor, an activity that requires the cysteine 245 residue. Frameshift mutations in caspase-5 have been identified in MMP tumors of the endometrium, colon, and stomach, indicating the caspase-5 may be a new target gene in the microsatellite mutator pathway for cancer. The human caspase 5 gene maps to chromosome 11q22.2-q22.3 and encodes a protein whose expression is barely detectable in most tissues except brain, with highest expression levels being found in lung, liver and skeletal muscle.

Specifications

Catalog number

ET1612-29

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Caspase5 Apoptosis related cysteine protease antibody CASP-5 antibody CASP5 antibody CASP5_HUMAN antibody Caspase-5 subunit p10 antibody Caspase-5 antibody Caspase 5 antibody Caspase5 antibody ICE (rel)-III antibody ICERELIII antibody ICH 3 antibody ICH 3 protease antibody Protease ICH-3 antibody Protease TY antibody TY antibody TY protease antibody

Abbreviation

CASP-5, CASP5

Swiss Prot

P51878 Human

Cellular Locus

NLRP1 inflammasome complex, cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human Caspase 5 aa 1-50 / 434.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP

Positive Control

A549, Hela, SHG-44, human liver tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 50 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes