Angiotensinogen Recombinant Rabbit Monoclonal Antibody [SD201-02]

About this product

Angiotensin is formed from a precursor, angiotensinogen, which is produced by the liver and found in the a-globulin fraction of plasma. The lowering of blood pressure is a stimulus to secretion of Renin by the kidney into the blood. Renin cleaves from angiotensinogen a terminal decapeptide, Angiotensin I (Ang I). This is further altered by the enzymatic removal of a dipeptide to form Angiotensin II (Ang II). Screening a panel of human-mouse somatic cell hybrids confirmed the assignment of the AGT locus to human chromosome 1. Angiotensin, an octapeptide hormone, is an important physiological effector of blood pressure and volume regulation through vasoconstriction, aldosterone release, sodium uptake and thirst stimulation. It has been shown that mechanical stress causes release of Angiotensin from cardiac myocytes and that Angiotensin acts as an initial mediator of the hypertrophic response. Angiotensin treatment also stimulates phosphorylation of Shc, FAK and MAP kinases and induces MKP-1, indicating stimulation of growth factor pathways. Angiotensin stimulation through AT1 has been shown to activate the JAK/Stat pathway involving a direct interaction between JAK2 and AT1 as demonstrated by co-immunoprecipitation.

Specifications

Catalog number

ET1612-48

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Aangiotensinogen (serpin peptidase inhibitor clade A member 8) antibody AGT antibody AI265500 antibody Alpha 1 antiproteinase antitrypsin antibody Ang antibody Ang I antibody Ang II antibody Ang III antibody AngII antibody Angiotensin I antibody Angiotensin II antibody Angiotensin III antibody Angiotensin-3 antibody Angiotensinogen (PAT) antibody Angiotensinogen antibody ANGT_HUMAN antibody ANHU antibody ANRT antibody AT-2 antibody AT-II antibody Des-Asp[1]-angiotensin II antibody FLJ92595 antibody FLJ97926 antibody MGC105326 antibody PAT antibody Pre angiotensinogen antibody Serine (or cysteine) proteinase inhibitor antibody Serpin A8 antibody Serpin peptidase inhibitor clade A member 8 antibody SERPINA8 antibody

Abbreviation

AGT

Swiss Prot

P01019 Human

Cellular Locus

Secreted.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein Human Angiotensinogen aa 361-485 / 485.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IP

Positive Control

LO2, 293, Hela, HepG2.

Concentration

1 mg/mL

Dilution

WB: 1:1,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

53 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes