TRAF2 Recombinant Rabbit Monoclonal Antibody [SD205-06]

About this product

Tumor necrosis factor (TNF)-activated cell signaling is mediated primarily through the TNF receptor 1 (TNF-R1) and, to a lesser extent, TNF-R2. Both TNF receptors are members of the expanding TNF receptor superfamily, which includes the FAS antigen and CD40. Potential insight into an understanding of TNF receptor-mediated signaling was provided by the identification of two related proteins, TRAF1 and TRAF2 (for TNF receptor-associated factors 1 and 2, respectively). Both function to form heterodimeric complexes and associate with the cytoplasmic domain of TNF-R2. A third member of this protein family, alternatively designated CD40 bp, CRAF1, LAP1 or TRAF3, has been identified and shown to associate with the cytoplasmic domain of CD40. The similarity between a specific region of TRAF3 with regions of TRAF1 and TRAF2 define a “TRAF-C” domain that is necessary and sufficient for CD40 binding and homodimerization.

Specifications

Catalog number

ET1612-5

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

E3 ubiquitin-protein ligase TRAF2 antibody MGC:45012 antibody OTTHUMP00000022625 antibody OTTHUMP00000064745 antibody TNF receptor associated factor 2 antibody TNF receptor-associated factor 2 antibody TNF receptor-associated protein antibody TRAF 2 antibody TRAF2 antibody TRAF2_HUMAN antibody TRAP 3 antibody TRAP antibody TRAP3 antibody Tumor necrosis factor type 2 receptor associated protein 3 antibody Tumor necrosis factor type 2 receptor-associated protein 3 antibody

Abbreviation

TRAF2

Swiss Prot

Q12933 Human, P39429 Mouse

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within N-terminal human TRAF2.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Tissue, IHC-P, IP

Positive Control

HeLa cell lysate, K-562 cell lysate, C2C12 cell lysate, mouse liver tissue lysate, rat liver tissue lysate, human kidney tissue, human pancreas tissue, human liver tissue, mouse placenta tissue.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:5,000 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 56 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes