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![HDAC2 Recombinant Rabbit Monoclonal Antibody [SD0816] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8c061270361ea81d45/imageurl/et1612-50.webp)
Product details
Catalog number ET1612-50
Price for ET1612-50
Size / count 100 µL
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. Acetylation of lysine residues in the amino terminal tail domain of histone results in an allosteric change in the nucleosomal conformation and an increased accessibility to transcription factors by DNA. Conversely, the deacetylation of histones is associated with transcriptional silencing. Several mammalian proteins have been identified as nuclear histone acetylases, including GCN5, PCAF (for p300/CBP-associated factor), p300/CBP and the TFIID subunit TAF II p250. Mammalian HDAC1 (also designated HD1) and HDAC2 (also designated mammalian RPD3), both of which are related to the yeast transcriptional regulator Rpd3p, have been identified as histone deacetylases.
The catalog number for HDAC2 Recombinant Rabbit Monoclonal Antibody [SD0816] is ET1612-50.
HDAC2 Recombinant Rabbit Monoclonal Antibody [SD0816] is available in the following size(s): 100 µL.
HDAC2 Recombinant Rabbit Monoclonal Antibody [SD0816] is currently made to order / not held in immediate stock. Contact us for lead time.
In the intact cell, DNA closely associates with histones and other nuclear proteins to form chromatin. The remodeling of chromatin is believed to be a critical component of transcriptional regulation and a major source of this remodeling is brought about by the acetylation of nucleosomal histones. A
Cross-reactivity data, based on available testing, is listed under the reactivity section of the datasheet. Contact us if you need reactivity confirmed for a species not listed.
Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.
We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.
