TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0] — image 1 of 3

Product details

TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0]

Catalog number ET1612-52

Price for ET1612-52

Size / count 100 µL

About this product

Oncogenic rearrangements of the NTRK1 gene, which encodes the Trk A protein, are frequently detected in thyroid carcinomas. Such rearrangements fuse the NTRK1 tyrosine kinase domain to 5'-end sequences of different genes. TRK-T3 contains 1,412 nucleotides of NTRK1 preceded by 598 nucleotides belonging to TFG (TRK-fused gene), a ubiquitously expressed gene located on chromosome 3. The TRK-T3 protein within the TFG region contains a coiled-coil motif that gives the oncoprotein the capability to form complexes. The cytoplasmic TRK-T3 protein binds to and phosphorylates the Shc and SNT1/FRS2 adaptor proteins, both of which are involved in coupling the receptor tyrosine kinase to the mitogen-activated protein kinase pathway by recruiting Grb2/SOS. SHP-1 also interacts with and down-regulates TRK-T3.

Specifications

Catalog number: ET1612-52
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FLJ36137 antibody HMSNP antibody OTTHUMP00000214045 antibody OTTHUMP00000214046 antibody OTTHUMP00000214047 antibody OTTHUMP00000214048 antibody Protein TFG antibody SPG57 antibody TF6 antibody TFG antibody TFG_HUMAN antibody TRK fused antibody TRK fused gene antibody TRK fused gene protein antibody TRK-fused gene protein antibody TRKT3 antibody TRKT3 oncogene antibody
Abbreviation: TFG
Swiss Prot: Q92734 Human
Cellular Locus: Endoplasmic reticulum.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human TRK aa 351-400 / 400.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP
Positive Control: 293T cell lysate, Hela cell lysate, Hela, SKOV-3, A549, human tonsil tissue, mouse colon tissue, mouse kidney tissue, human lung carcinoma tissue, human kidney tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000;IF-Cell: 1:50-1:200;IF-Tissue: 1:50-1:200;IHC-P: 1:50-1:200;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: 43 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0]?

The catalog number for TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0] is ET1612-52.

What sizes are available for TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0]?

TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0] is available in the following size(s): 100 µL.

Is TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0] in stock?

TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0] is currently made to order / not held in immediate stock. Contact us for lead time.

What is TRK fused gene Recombinant Rabbit Monoclonal Antibody [SD082-0] used for?

What should I do if I need to report a performance issue with a specific lot of this product?

Provide the catalogue number, product name, lot number, and your experimental results to our technical support team. They’ll investigate and, if needed, escalate to the manufacturer, provided the product was used before expiry and stored correctly.

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.