FGFR1 Recombinant Rabbit Monoclonal Antibody [SD08-25]

About this product

Acidic and basic fibroblast growth factors (FGFs) are members of a family of multifunctional polypeptide growth factors that stimulate proliferation of cells of mesenchymal, epithelial and neuroectodermal origin. Like other growth factors, FGFs act by binding and activating specific cell surface receptors. These include the Flg receptor (FGFR-1), the Bek receptor (FGFR-2), FGFR-3, FGFR-4, FGFR-5 and FGFR-6. These receptors usually contain an extracellular ligand-binding region containing three immunoglobulin-like domains, a transmembrane domain and a cytoplasmic tyrosine kinase domain. The gene encoding human Flg maps to chromosome 8p12 and is alternatively spliced to produce several isoforms. Mutations in Flg are associated with Pfeiffer syndrome (a skeletal disorder characterized by craniosynostosis with deviation and enlargement of the thumbs and great toes), brachymesophalangy with phalangeal ankylosis and a varying degree of soft tissue syndactyly. The Flg gene is also involved in chromosomal translocations with ZNF198, CEP110 and FOP, which may lead to stem cell leukemia lymphoma (SCLL).

Specifications

Catalog number

ET1612-62

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Basic fibroblast growth factor receptor 1 antibody bFGF-R-1 antibody BFGFR antibody CD331 antibody CEK antibody FGFBR antibody FGFR 1 antibody FGFR-1 antibody FGFR1 antibody FGFR1/PLAG1 fusion antibody FGFR1_HUMAN antibody fibroblast growth factor receptor 1 antibody FLG antibody FLT-2 antibody FLT2 antibody Fms-like gene antibody Fms-like tyrosine kinase 2 antibody fms-related tyrosine kinase 2 antibody HBGFR antibody heparin-binding growth factor receptor antibody HH2 antibody HRTFDS antibody hydroxyaryl-protein kinase antibody KAL2 antibody N-SAM antibody OGD antibody Proto-oncogene c-Fgr antibody

Abbreviation

FGFR-1, BFGFR, bFGF-R-1, FLT-2, FGFR1

Swiss Prot

P11362 Human

Cellular Locus

Cell membrane, Nucleus, Cytoplasm.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human FGFR1 aa 766-822 / 822.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell

Positive Control

U-87 MG cell lysate, U-87 MG.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;IF-Cell: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 92 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes