ERK5 Recombinant Rabbit Monoclonal Antibody [SD2084]

About this product

The activation of signal transduction pathways by growth factors, hormones and neurotransmitters is mediated through two closely related MAP kinases, p44 and p42, designated extracellular-signal related kinase 1 (ERK 1) and ERK 2, respectively. ERK proteins are regulated by dual phosphorylation at specific tyrosine and threonine sites mapping within a characteristic Thr-Glu-Tyr motif. Phosphorylation at both the Thr and Tyr residues is required for full enzymatic activation. In response to activation, MAP kinases phosphorylate downstream components on serine and threonine. Upstream MAP kinase regulators include MAP kinase kinase (MEK), MEK kinase and Raf-1. The ERK family has three additional members: ERK 3, ERK 5 and ERK 6.

Specifications

Catalog number

ET1612-7

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Big MAP kinase 1 antibody BMK 1 antibody BMK 1 kinase antibody BMK-1 antibody BMK1 antibody BMK1 Kinase antibody EC 2.7.11.24 antibody ERK 4 antibody ERK 5 antibody ERK-5 antibody ERK4 antibody ERK5 antibody Extracellular signal regulated kinase 5 antibody Extracellular signal-regulated kinase 5 antibody MAP kinase 7 antibody MAPK 7 antibody MAPK7 antibody Mitogen activated protein kinase 7 antibody Mitogen-activated protein kinase 7 antibody MK07_HUMAN antibody OTTHUMP00000065906 antibody OTTHUMP00000065907 antibody PRKM 7 antibody PRKM7 antibody PROTEIN KINASE, MITOGEN-ACTIVATED, 7 antibody

Abbreviation

MAP kinase 7, MAPK 7, BMK-1, ERK-5, MAPK7

Swiss Prot

Q13164 Human, Q9WVS8 Mouse, P0C865 Rat

Cellular Locus

Cytoplasm, Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic peptide within Human ERK5 aa 767-816 / 816.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IP, FC

Positive Control

HeLa cell lysate, NIH/3T3 cell lysate, Neuro-2a cell lysate, mouse brain tissue lysate, mouse testis tissue lysate, PC-12 cell lysate, NIH/3T3, PC-12, HeLa.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IF-Cell: 1:100 ;IF-Tissue: 1:100-1:500 ;FC: 1:1,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 88 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes