Phospho-CDC37 (S13) Recombinant Rabbit Monoclonal Antibody [SD08-50]

About this product

Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases (Cdks) and by the proteolysis of cyclins. The cell division cycle (Cdc) genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with Hsp90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC (anaphase-promoting complex) which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Specifications

Catalog number

ET1612-74

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CDC 37 antibody Cdc37 antibody CDC37 cell division cycle 37 homolog antibody CDC37 cell division cycle 37 S cerevisiae homolog antibody CDC37 cell division cycle 37, S cerevisiae, homolog of antibody Cdc37 homolog antibody CDC37 protein antibody CDC37_HUMAN antibody CDC37A antibody cell division cycle 37 antibody Cell division cycle 37 homolog antibody Hsp90 chaperone protein kinase targeting subunit antibody Hsp90 chaperone protein kinase targeting subunit p50Cdc37 antibody Hsp90 chaperone protein kinase-targeting subunit antibody Hsp90 co chaperone Cdc37 antibody Hsp90 co-chaperone Cdc37 antibody p50 antibody p50Cdc37 antibody S cerevisiae hypothetical protein CDC37 antibody

Abbreviation

CDC37

Swiss Prot

Q16543 Human, Q61081 Mouse, Q63692 Rat

Cellular Locus

Cytoplasm.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Synthetic phospho-peptide corresponding to residues surrounding Ser13 of human CDC37.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IP

Positive Control

HEK-293 cell lysate, HeLa cell lysate, C2C12 cell lysate, PC-12 cell lysate, HEK-293 cell lysate treated with λpp for 1 hour, C2C12 cell lysate treated with λpp for 1 hour.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:2,000 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 45 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes