PAX6 Recombinant Rabbit Monoclonal Antibody [SD08-31]

About this product

Pax genes contain paired domains with strong homology to genes in Drosophila which are involved in programming early development. Lesions in the Pax-6 gene account for most cases of aniridia, a congenital malformation of the eye, chiefly characterized by iris hypoplasia, which can cause blindness. Pax-6 is involved in other anterior segment malformations besides aniridia, such as Peters anomaly, a major error in the embryonic development of the eye with corneal clouding with variable iridolenticulocorneal adhesions. The Pax-6 gene encodes a transcriptional regulator that recognizes target genes through its paired-type DNA-binding domain. The paired domain is composed of two distinct DNA-binding subdomains, the amino-terminal subdomain and the carboxy-terminal subdomain, which bind respective consensus DNA sequences. The human Pax-6 gene produces two alternatively spliced isoforms that have the distinct structure of the paired domain.

Specifications

Catalog number

ET1612-89

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

AN 2 antibody AN antibody AN2 antibody Aniridia type II protein antibody D11S812E antibody FVH1 antibody KIAA0552 antibody Leucine zipper putative tumor suppressor 3 antibody LZTS3 antibody MGC17209 antibody MGDA antibody Oculorhombin antibody Paired box 6 antibody Paired box gene 6 (aniridia keratitis) antibody Paired Box Gene 6 antibody Paired box homeotic gene 6 antibody Paired box protein Pax-6 antibody Paired box protein Pax6 antibody PAX 6 antibody PAX6 antibody PAX6_HUMAN antibody ProSAP-interacting protein 1 antibody PROSAPIP1 antibody Sey antibody WAGR antibody

Abbreviation

PAX6

Swiss Prot

P26367 Human, P63015 Mouse, P63016 Rat

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human, Mouse, Rat

Immunogen

Recombinant protein within Human PAX6 aa 152-351 / 422.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, FC

Positive Control

HeLa cell lysate, 293T cell lysate, RAW264.7 cell lysate, Mouse cerebellum tissue lysate, Rat cerebellum tissue lysate, human pancreas tissue, mouse cerebellum tissue, rat cerebellum tissue, mouse eyeball tissue, rat eyeball tissue, mouse pancreas tissue, rat pancreas tissue, rat retina tissue, 293T, RAW264.7 .

Concentration

1 mg/mL

Dilution

WB: 1:5,000 ;IF-Cell: 1:50 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:1,000 ;FC: 1:1,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 47 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes