HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07] — image 1 of 2

Product details

HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07]

Catalog number ET1612-90

Price for ET1612-90

Size / count 100 µL

About this product

Histone deacetylase 8 is an enzyme that in humans is encoded by the HDAC8 gene. Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation / deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase/acuc/apha family. It has histone deacetylase activity and represses transcription when tethered to a promoter. Histone deacetylase 8 is involved in skull morphogenesis and metabolic control of the ERR-alpha / PGC1-alpha transcriptional complex. HDAC8 has been linked to number of disease states notably to acute myeloid leukemia and is related to actin cytoskeleton in smooth muscle cells. siRNA targeting HDAC8 showed anticancer effects. Inhibition of HDAC8 induced apoptosis has been observed in T cell lymphomas. In addition the HDAC8 enzyme has been implicated in the pathogenesis of neuroblastoma.

Specifications

Catalog number: ET1612-90
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: CDA07 antibody CDLS5 antibody HD 8 antibody HD8 antibody HDAC 8 antibody Hdac8 antibody HDAC8_HUMAN antibody HDACL 1 antibody HDACL1 antibody Histone deacetylase 8 antibody Histone deacetylase like 1 antibody MRXS6 antibody RPD 3 antibody RPD3 antibody WTS antibody
Abbreviation: HD8, HDAC8
Swiss Prot: Q9BY41 Human, Q8VH37 Mouse, B1WC68 Rat
Cellular Locus: Nucleus, Cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Synthetic peptide within Human HDAC8 aa 61-110 / 377.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, FC, IP
Positive Control: K562 cell lysate, Hela cell lysate, K562.
Concentration: 1 mg/mL
Dilution: WB: 1:500-1:2,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 42 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07]?

The catalog number for HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07] is ET1612-90.

What sizes are available for HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07]?

HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07] is available in the following size(s): 100 µL.

Is HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07] in stock?

HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07] is currently made to order / not held in immediate stock. Contact us for lead time.

What is HDAC8 Recombinant Rabbit Monoclonal Antibody [SD082-07] used for?

How do I reconstitute this lyophilized product?

Reconstitution instructions, including the recommended diluent and final concentration, are provided on the datasheet. Aliquot immediately after reconstitution to avoid repeated freeze-thaw cycles.

What is the recommended incubation time for this antibody?

A suggested incubation time is provided in the recommended protocol on the datasheet, but may need adjusting depending on your sample type and detection system.

What should I check when this product first arrives?

Inspect the package immediately for transportation damage, ice loss, leakage, or breakage. Report any issues right away with photos and your order reference; our specialists will determine whether the product is still usable or needs replacing.