Cytokeratin 2e Recombinant Rabbit Monoclonal Antibody [JJ201-8]

About this product

The keratin multigene family is made of "soft" epithelial cytokeratins and "hard" hair keratins. While the epithelial cytokeratins are involved in the layering and formation of epithelia, the hair keratins are responsible for creating nails and hair. There are two types of keratins: the acidic class I keratin proteins and the basic/neutral class II keratin proteins. Keratin 2 (KRT2), also known as Keratin type II cytoskeletal 2 epidermal, Keratin-2e (K2e), KRTE, Cytokeratin-2e (CK-2e), KRT2A or KRT2E, is a 639 amino acid class II epithelial Keratin protein belonging to the intermediate filament family. Encoded by a gene that maps to human chromosome 12q13.13, Keratin 2 functions in epidermal keratinocyte activation and proliferation, and plays a part in terminal cornification. Highly expressed in upper epithelial tissues, Keratin 2 forms heterotetramers with two class I Keratins and another class II Keratin. Defects in Keratin 2 have been linked to ichthyosis bullosa of Siemens (IBS), a rare autosomal dominant skin disorder.

Specifications

Catalog number

ET1701-13

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CK 2e antibody CK2e antibody Cytokeratin-2e antibody Epithelial keratin-2e antibody K2e antibody Keratin type II cytoskeletal 2 epidermal antibody Keratin-2 epidermis antibody KRT2 antibody KRT2A antibody KRT2E antibody Type-II keratin Kb2 antibody

Abbreviation

CK-2e, K2e, KRT2

Swiss Prot

P35908 Human

Cellular Locus

Cytoplasm, Membrane, Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within Human Cytokeratin 2e aa 273-442 / 639.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IHC-P

Positive Control

Human skin tissue lysates, human tonsil tissue, human esophagus tissue.

Concentration

1 mg/mL

Dilution

WB: 1:500-1:1,000 ;IHC-P: 1:50-1:100

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 65 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes