SIRT6 Recombinant Rabbit Monoclonal Antibody [JJ20-69]

About this product

Sirtuin 6 (SIRT6 or Sirt6) is a stress responsive protein deacetylase and mono-ADP ribosyltransferase enzyme encoded by the SIRT6 gene. In laboratory research, SIRT6 appears to function in multiple molecular pathways related to aging, including DNA repair, telomere maintenance, glycolysis and inflammation. SIRT6 is member of the mammalian sirtuin family of proteins, which are homologs to the yeast Sir2 protein. Sirt6 is mainly known as a deacetylase of histones H3 and H4, an activity by which it changes chromatin density and regulates gene expression. The enzymatic activity of Sirt6, as well as of the other members of the sirtuins family, is dependent upon the binding of the cofactor nicotinamide adenine dinucleotide (NAD+). SIRT6 is a chromatin-associated protein that is required for normal base excision repair and double-strand break repair of DNA damage in mammalian cells. SIRT6 promotes the repair of DNA double-strand breaks by the process of non-homologous end joining and homologous recombination. SIRT6 stabilizes the repair protein DNA-PKcs (DNA-dependent protein kinase catalytic subunit) at chromatin sites of damage.

Specifications

Catalog number

ET1701-29

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

2810449N18Rik antibody AI043036 antibody Mono ADP ribosyltransferase sirtuin 6 antibody NAD-dependent protein deacetylase sirtuin-6 antibody Regulatory protein SIR2 homolog 6 antibody Regulatory protein SIR2 homolog antibody SIR2 like 6 antibody SIR2 like protein 6 antibody Sir2 related protein type 6 antibody SIR2-like protein 6 antibody SIR2L6 antibody SIR6_HUMAN antibody SIRT 6 antibody SIRT6 antibody Sirtuin (silent mating type information regulation 2 homolog) 6 (S. cerevisiae) antibody Sirtuin 6 antibody Sirtuin type 6 antibody Sirtuin6 antibody

Abbreviation

SIRT6

Swiss Prot

Q8N6T7 Human

Cellular Locus

Nucleus.

Host

Rabbit

Species Reactivity

Human

Immunogen

Synthetic peptide within Human SIRT6 aa 306-355 / 355.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB

Positive Control

HeLa cell lysate, MDA-MB-231 cell lysate.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 39 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes