SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83]

Catalog number ET1701-43

Price for ET1701-43

Size / count 100 µL

About this product

The silent information regulator (SIR2) family of genes are highly conserved from prokaryotes to eukaryotes and are involved in diverse processes, including transcriptional regulation, cell cycle progression, DNA-damage repair and aging. In S. cerevisiae, Sir2p deacetylates histones in a NAD-dependent manner, which regulates silencing at the telomeric, rDNA and silent mating-type loci. Sir2p is the founding member of a large family, designated sirtuins, which contain a conserved catalytic domain. The human homologs, which include SIRT1-7, are divided into four main branches: SIRT1-3 are class I, SIRT4 is class II, SIRT5 is class III and SIRT6-7 are class IV. SIRT proteins may function via mono-ADP-ribosylation of proteins. SIRT2 contains a 323 amino acid catalytic core domain with a NAD-binding domain and a large groove which is the likely site of catalysis.

Specifications

Catalog number: ET1701-43
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: FLJ35621 antibody FLJ37491 antibody NAD dependent deacetylase sirtuin 2 antibody NAD-dependent deacetylase sirtuin-2 antibody NAD-dependent protein deacetylase sirtuin-2 antibody Regulatory protein SIR2 homolog 2 antibody Silencing information regulator 2 like antibody Silent information regulator 2 antibody SIR2 antibody SIR2 like protein 2 antibody Sir2 related protein type 2 antibody SIR2, S. cerevisiae, homolog-loke 2 antibody SIR2-like protein 2 antibody SIR2L antibody SIR2L2 antibody SIRT2 antibody SIRT2_HUMAN antibody Sirtuin (silent mating type information regulation 2 homolog) 2 (S.cerevisiae) antibody Sirtuin 2 antibody Sirtuin type 2 antibody
Abbreviation: SIRT2
Swiss Prot: Q8IXJ6 Human
Cellular Locus: Cell membrane, Cell projection, Chromosome, Cytoplasm, Cytoskeleton, Membrane, Microtubule, Nucleus.
Host: Rabbit
Species Reactivity: Human
Immunogen: Synthetic peptide within Human SIRT2 aa 1-50 / 389.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB
Positive Control: MCF7 cell lysate, HeLa cell lysate, HCT 116 cell lysate, human brain tissue lysate.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000-1:2,000
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 43 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83]?

The catalog number for SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83] is ET1701-43.

What sizes are available for SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83]?

SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83] is available in the following size(s): 100 µL.

Is SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83] in stock?

SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83] is currently made to order / not held in immediate stock. Contact us for lead time.

What is SIRT2 Recombinant Rabbit Monoclonal Antibody [JJ08-83] used for?

Is there an additional fee for hazardous or dry ice shipping of this product?

Yes, if this product requires dry ice or is classed as hazardous for transport, the additional fee will be explicitly shown in your quotation before you confirm the order, so there are no surprise charges later.

How many freeze-thaw cycles can this product tolerate?

We recommend aliquoting the product upon receipt to avoid repeated freeze-thaw cycles, which can reduce activity and stability. This is your responsibility once the product has been delivered.

Is antigen retrieval required for IHC with this antibody?

Recommended antigen retrieval methods, where applicable, are listed on the datasheet under the IHC protocol section.