STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78] — image 1 of 3

Product details

STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78]

Catalog number ET1701-45

Price for ET1701-45

Size / count 100 µL

About this product

Stat5 (Signal Transducers and Activators of Transcription 5) is important in regulating T cell functions involving the receptors for Interleukin-2 (IL-2). IL-2 stimulates the rapid phosphorylation of both serine and tyrosine residues of Stat5a and Stat5b in human T lymphocytes and in several IL-2-responsive lymphocytic cell lines. IL-2 differentially induces serine phosphorylation of Stat5a and Stat5b on Ser726 and Ser731, respectively. Stat5b is preferentially phosphorylated and displays more protracted serine phosphorylation kinetics than Stat5a. Both the acid-rich region and the COOH terminus of IL-2Rb can independently mediate IL-2-induced Stat 5a/b serine phosphorylation, suggesting that Stat5a/b serine phosphorylation occurs at a postreceptor level. Stat5a is phosphorylated on Tyr694 in a prolactin-sensitive manner, whereas serine phosphorylation is constitutive. Activation of Stat5 by IL-2 may help govern the biological effects of IL-2 during the immune response.

Specifications

Catalog number: ET1701-45
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Mammary gland factor (STAT5A) antibody MGF (STAT5A) antibody Signal transducer and activator of transcription 5A antibody Signal transducer and activator of transcription 5B antibody STA5A_HUMAN antibody Stat 5a antibody STAT 5b antibody STAT5A antibody Transcription factor STAT5B antibody
Abbreviation: STAT5A, STAT5B
Swiss Prot: P42229 Human, P51692 Human, P42230 Mouse, P42232 Mouse, P52632 Rat, Q62771 Rat
Cellular Locus: Nucleus, Cytoplasm.
Host: Rabbit
Species Reactivity: Human, Mouse, Rat
Immunogen: Recombinant protein within mouse Stat5b aa 585-773 / 786.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IF-Cell, IF-Tissue, IHC-P, IP, FC
Positive Control: A549 cell lysate, HeLa cell lysate, NIH/3T3 cell lysate, PC-12 cell lysate, Mouse brain tissue lysate, Mouse testis tissue lysate, Rat ovary tissue lysate, PC-12, HepG2, NIH/3T3, human tonsil tissue, rat lymph node tissue, rat testis tissue, mouse brain tissue, human spleen tissue.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:50-1:400 ;FC: 1:1,000 ;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 90 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78]?

The catalog number for STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78] is ET1701-45.

What sizes are available for STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78]?

STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78] is available in the following size(s): 100 µL.

Is STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78] in stock?

STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78] is currently made to order / not held in immediate stock. Contact us for lead time.

What is STAT 5A+B Recombinant Rabbit Monoclonal Antibody [JJ08-78] used for?

What is the isotype of this antibody?

Isotype information such as IgG1 or IgG2a is listed in the product specifications on the datasheet, relevant for selecting compatible detection reagents.

Can I get a trial-size or discounted first order of this product?

We don’t generally offer free samples, but trial discounts in exchange for feedback and validation results are almost always possible. Contact us with your intended application to arrange one.

Do you offer bulk or custom quantities of this product?

Yes. Ordering two or more units, or combining this with other products, usually qualifies for a discount depending on quantity. Contact our sales team with your required volume for a custom quote.