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![PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88] — image 1 of 3](https://cdn.genprice.uk/products/992/68dd1c8b061270361ea814a7/imageurl/et1701-50.webp)
Product details
Catalog number ET1701-50
Price for ET1701-50
Size / count 100 µL
PAX8 is a transcription factor crucial to the organogenesis and development of the thyroid gland, urogenital tract, placenta and inner ear. In the thyroid, PAX8 is a master gene that regulates maintenance of the differentiated thyroid follicular cell phenotype, where it controls and activates the transcription of the main proteins responsible for the functional activity of follicular cells such as thyroglobulin, thyroperoxidase and sodium/iodide symporter. In the developing kidney PAX8 is important for renal vescicle formation. PAX8 regulates the expression of the WT1 gene. PAX8 appears to be currently the most sensitive and specific marker for renal cell carcinoma and ovarian non-mucinous carcinoma. Follicular and papillary thyroid carcinoma are virually always PAX8 positive (while anaplastic carcinoma is positive in most cases and medullary thyroid carcinoma negative). PAX8 is also found in almost all cases of ovarian serous, endometrioid, transitional and clear cell carcinoma (while mucinous carcinoma is positive in a minor number of cases), and endometrial carcinoma.
The catalog number for PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88] is ET1701-50.
PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88] is available in the following size(s): 100 µL.
PAX8 Recombinant Rabbit Monoclonal Antibody [JJ08-88] is currently made to order / not held in immediate stock. Contact us for lead time.
PAX8 is a transcription factor crucial to the organogenesis and development of the thyroid gland, urogenital tract, placenta and inner ear. In the thyroid, PAX8 is a master gene that regulates maintenance of the differentiated thyroid follicular cell phenotype, where it controls and activates the tr
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