Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890] — image 1 of 3

Product details

Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890]

Catalog number ET1701-53

Price for ET1701-53

Size / count 100 µL

About this product

Caspase-10, also designated Mch4, is recruited to the native TRAIL and CD9 death-inducing signaling complexes (DISCs) by the FADD/Mort1 adaptor protein complex. Caspase-10 requires the assembly of the FADD and DISC complexes for its recruitment and cleavage-induced activation during CD95-induced apoptosis of activated T cells. The N-terminus of caspase-10 contains FADD-like death effector domains further indicating that it associates with FADD to induce apoptosis. Caspase-10 is not required for apoptosis induction and when overexpressed, cannot reverse defects in apoptosis induction caused by caspase-8 deficiency. Granzyme B cleaves procaspase-10 at an IXXD-A processing sequence to produce mature caspase-10. Mutations in the caspase-10 gene in the prodomain, p17 large protease subunit and p12 small protease subunit have been linked to a number of non-Hodgkin lymphomas in humans.

Specifications

Catalog number: ET1701-53
Size / count: 100 µL
Dry ice: No
Hazardous: No
Discontinued: No
CAS Number: 9000-83-3
Product Name Alternative: Caspase10 ALPS2 antibody Apoptotic protease Mch-4 antibody CASP 10 antibody CASP-10 antibody CASP10 antibody CASPA_HUMAN antibody Caspase 10 apoptosis related cysteine peptidase antibody Caspase-10 subunit p12 antibody FADD like ICE2 antibody Fas associated death domain protein antibody FAS-associated death domain protein interleukin-1B-converting enzyme 2 antibody FLICE 2 antibody FLICE2 antibody ICE like apoptotic protease 4 antibody ICE-like apoptotic protease 4 antibody Interleukin 1B converting enzyme 2 antibody MCH 4 antibody
Abbreviation: CASP-10, FLICE2, CASP10
Swiss Prot: Q92851 Human
Cellular Locus: Cytosol.
Host: Rabbit
Species Reactivity: Human
Immunogen: Recombinant protein within Human Caspase-10 aa 254-452 / 521.
Isotype: IgG
Conjugation: Non-conjugated
Type: Recombinant Rabbit monoclonal Antibody
Applications: WB, IHC-P, FC, IP
Positive Control: K562 cell lysates, human liver carcinoma tissue, human kidney tissue, K562.
Concentration: 1 mg/mL
Dilution: WB: 1:1,000-1:2,000 ;FC: 1:50-1:100 ;IHC-P: 1:50-1:200 ;IP: Use at an assay dependent concentration.
Purity: Protein A affinity purified.
Form: Liquid
Buffer: 1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Molecular Weight: Predicted band size: 59 kDa
Storage Conditions: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Recombinant Antibody: Yes

Frequently Asked Questions

What is the catalog number for Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890]?

The catalog number for Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890] is ET1701-53.

What sizes are available for Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890]?

Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890] is available in the following size(s): 100 µL.

Is Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890] in stock?

Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890] is currently made to order / not held in immediate stock. Contact us for lead time.

What is Caspase-10 Recombinant Rabbit Monoclonal Antibody [JJ0890] used for?

What do I do if this product arrives with reduced ice or a damaged cold-chain package?

Report this to us immediately with photos and your order reference. Our specialists will assess whether the product is still usable given the cold-chain interruption, and will arrange a replacement or credit if it isn’t.

What host species was used to raise this antibody?

The host species used in production is listed under product specifications on the datasheet, and is relevant when selecting a compatible secondary antibody for your assay.

What is the difference between this product and a similar catalogue number?

Differences typically involve clone, conjugate, host species, or validated applications. Compare the respective datasheets, or contact us with both catalogue numbers for a direct comparison.