Integrin alpha 5 Recombinant Rabbit Monoclonal Antibody [JJ08-94]

About this product

Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including Fibronectin, Collagen and Vitronectin. Certain integrins can also bind to soluble ligands such as Fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Specifications

Catalog number

ET1701-58

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

CD49 antigen-like family member E antibody CD49e antibody Fibronectin receptor subunit alpha antibody Fibronectin receptor, alpha subunit antibody FNRA antibody Integrin alpha 5 (fibronectin receptor alpha) antibody Integrin alpha-5 antibody Integrin alpha-5 light chain antibody Integrin alpha-F antibody Integrin, alpha 5 (fibronectin receptor, alpha polypeptide) antibody ITA5_HUMAN antibody Itga5 antibody Very late activation protein 5, alpha subunit antibody VLA-5 antibody VLA5 antibody VLA5A antibody

Abbreviation

ITGA5

Swiss Prot

P08648 Human, P11688 Mouse

Cellular Locus

Membrane, Cell junction, Cell surface.

Host

Rabbit

Species Reactivity

Human, Mouse, Monkey, Rat

Immunogen

Synthetic peptide within C-terminal human Integrin alpha 5.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, IHC-P, IP, FC

Positive Control

HeLa cell lysate, A549 cell lysate, U-937 cell lysate, NIH/3T3 cell lysate, COS-1 cell lysate, Mouse liver tissue lysate, Rat liver tissue lysate, NIH/3T3, human kidney tissue, human placenta tissue, human tonsil tissue, mouse endometrium tissue, Hela, Jurkat.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000 ;IF-Cell: 1:50-1:200 ;IF-Tissue: 1:50-1:200 ;IHC-P: 1:200-1:1,000 ;FC: 1:50-1:100 ;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 115 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes