RIP Recombinant Rabbit Monoclonal Antibody [JJ092-04]

About this product

In contrast to growth factors which promote cell proliferation, FAS ligand (FAS-L) and the tumor necrosis factors (TNFs) rapidly induce apoptosis. Cellular response to FAS-L and TNF is mediated by structurally related receptors containing a conserved "death domain" and belonging to the TNF receptor superfamily. TRADD, FADD and RIP are FAS/TNF-R1 interacting proteins that contain a death domain homologous region (DDH). TRADD (TNF-R1-associated death domain) and FADD (FAS-associated death domain) associate with the death domains of both FAS and TNF-R1 via their DDH regions. Overexpression of TRADD leads to NFkB activation and apoptosis in the absence of TNF. Overexpression of FADD causes apoptosis, which can be blocked by the cow pox protein CrmA, suggesting that FADD lies upstream of ICE and possibly other serine proteases. The receptor interacting protein, RIP, associates with FAS exclusively via its DDH and this association is abrogated in lpr mutants. Unlike TRADD and FADD, RIP contains a putative amino terminal kinase domain.

Specifications

Catalog number

ET1701-79

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

Cell death protein RIP antibody FLJ39204 antibody OTTHUMP00000039163 antibody Receptor (TNFRSF) interacting serine threonine kinase 1 antibody receptor interacting protein 1 antibody Receptor interacting protein antibody Receptor interacting protein kinase 1 antibody Receptor interacting serine threonine protein kinase 1 antibody Receptor TNFRSF interacting serine threonine kinase 1 antibody Receptor-interacting protein 1 antibody Receptor-interacting serine/threonine-protein kinase 1 antibody Rinp antibody RIP 1 antibody RIP antibody Rip-1 antibody RIP1 antibody RIPK 1 antibody Ripk1 antibody RIPK1_HUMAN antibody Serine threonine protein kinase RIP antibody Serine/threonine-protein kinase RIP antibody

Abbreviation

RIP-1, RIPK1

Swiss Prot

Q13546 Human

Cellular Locus

Cell membrane, Cytoplasm, Membrane.

Host

Rabbit

Species Reactivity

Human

Immunogen

Recombinant protein within human RIP aa 250-500.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, FC, IP

Positive Control

HeLa cell lysates, Raji cell lysates, 293.

Concentration

1 mg/mL

Dilution

WB: 1:1,000 ;FC: 1:1,000 ;IP: 1-2μg/sample

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 76 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes