SUMO4 Recombinant Rabbit Monoclonal Antibody [JJ085-01]

About this product

The small ubiquitin-related modifier (SUMO) proteins, which include SUMO-1, SUMO-2, SUMO-3 and SUMO-4, belong to the ubiquitin-like protein family. Like ubiquitin, the SUMO proteins are synthesized as precursor proteins that undergo processing before conjugation to target proteins. Ubiquitin and SUMO proteins utilize the E1, E2 and E3 cascade enzymes for conjugation. However, SUMO and ubiquitin differ with respect to targeting. Ubiquitination predominantly targets proteins for degradation, whereas sumoylation targets proteins for a variety of cellular processing, including nuclear transport, transcriptional regulation, apoptosis and protein stability. The unconjugated SUMO-1, SUMO-2, SUMO-3 and SUMO-4 proteins localize to the nucleus. In contrast to the other SUMO proteins, SUMO-4 seems to be insensitive to sentrin-specific proteases due to the presence of Pro-90, which may impair processing to mature form and conjugation to substrates. It is suggested that defects in the gene that encodes for the SUMO-4 protein may be involved in the pathogenesis of type I diabetes.

Specifications

Catalog number

ET1701-8

Size / count

100 µL

Dry ice

No

Hazardous

No

Discontinued

No

CAS Number

9000-83-3

Product Name Alternative

dJ281H8.4 antibody IDDM5 antibody Small ubiquitin like modifier 4 protein antibody Small ubiquitin-like protein 4 antibody Small ubiquitin-related modifier 4 antibody SMT3 suppressor of mif two 3 homolog 2 antibody SMT3 suppressor of mif two 3 homolog 4 (S. cerevisiae) antibody SMT3H4 antibody SUMO 4 antibody SUMO-4 antibody SUMO4 antibody SUMO4_HUMAN antibody

Abbreviation

SUMO-4, SUMO4

Swiss Prot

Q6EEV6 Human, P61957 Mouse, P61959 Rat

Cellular Locus

Nucleus, SUMO ligase complex.

Host

Rabbit

Species Reactivity

Human, Rat, Mouse

Immunogen

Recombinant protein within Human SUMO4 aa1-105 / 95.

Isotype

IgG

Conjugation

Non-conjugated

Type

Recombinant Rabbit monoclonal Antibody

Applications

WB, IF-Cell, IF-Tissue, FC, IP

Positive Control

293T cell lysate, Jurkat cell lysate, 293, MCF-7, HepG2, RH-35.

Concentration

1 mg/mL

Dilution

WB: 1:1,000-1:2,000;FC: 1:50-1:100;IF-Cell: 1:100-1:500;IF-Tissue: 1:100-1:500;IP: Use at an assay dependent concentration.

Purity

Protein A affinity purified.

Form

Liquid

Buffer

1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

Molecular Weight

Predicted band size: 11 kDa

Storage Conditions

Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Recombinant Antibody

Yes